Hemodynamic Effects on Systemic Blood Flow and Ductal Shunting Flow after Loading Dose of Intravenous Caffeine in Preterm Infants according to the Patency of Ductus Arteriosus.

CONCLUSION: In preterm infants with PDA, a standard intravenous loading dose of 20 mg/kg caffeine citrate was associated with increasing ductal shunting flow and decreasing SVC flow (as a surrogate for systemic blood flow) 1 hour after caffeine loading, however, these hemodynamic parameters recovered at 4 hours according to partial constriction of the ductus arteriosus. Close monitoring of hemodynamic changes would be needed to observe the risk for pulmonary over-circulation or systemic hypo-perfusion due to transient increasing ductal shunting flow during caffeine loading in preterm infants with PDA. PMID: 29318792 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/29318792?dopt=Abstract

Source: J Korean Med Sci - January 11, 2018 Category: General Medicine Authors: Hwang J, Kim YS, Shin JH, Choi BM Tags: J Korean Med Sci Source Type: research