Brazilian teen becomes fifth person cured of rabies

Mateus dos Santos da Silva, from Rio Unini, contacted the virus last November. He had a pioneering treatment that saw him placed in an induced coma to protect his brain,
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Conclusions/SignificanceTo help close the gap between efficacy and effectiveness in NTD programs, it is important that field staff: 1) generate meaningful knowledge about contextual factors; 2) use this knowledge to tailor field strategies; and 3) create routine mechanisms to account for the dynamic process of implementation itself. The framework presented here offers a simple analytical tool to strengthen these knowledge-to-action relationships existing project planning tools, drawing on the insights of socio-anthropology.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Vector-Borne and Zoonotic Diseases, Ahead of Print.
Source: Vector-Borne and Zoonotic Diseases - Category: Infectious Diseases Authors: Source Type: research
Abstract Background Among other applications, immunotherapy is used for the post-exposure treatment and/or prophylaxis of important infectious diseases, such as botulism, diphtheria, tetanus and rabies. The effectiveness of serum therapy is widely proven, but improvements on the immunoglobulin purification process and on the quality control are necessary to reduce the amount of protein aggregates. These may trigger adverse reactions in patients by activating the complement system and inducing the generation of anaphylatoxins. Herein, we used immunochemical methods to predict the quality of horse F(ab ′ )2 anti-botuli...
Source: Journal of Venomous Animals and Toxins including Tropical Diseases - Category: Tropical Medicine Source Type: research
Abstract Sleep is frequently altered in systemic infections as a component of sickness behavior in response to inflammation. Sleepiness in sickness behavior has been extensively investigated. Much less attention has instead been devoted to sleep and wake alterations in brain infections. Most of these, as other neuroinfections, are prevalent in sub-Saharan Africa. The present overview highlights the importance of this topic from both the clinical and pathogenetic points of view. Vigilance states and their regulation are first summarized, emphasizing that key nodes in this distributed brain system can be targeted by...
Source: Brain Research Bulletin - Category: Neurology Authors: Tags: Brain Res Bull Source Type: research
With the exception of salmonellosis, deaths from Rocky Mountain spotted fever (RMSF) * have exceeded those of other reportable zoonoses in the United States for most of the past six decades. [1,2]    Rabies was the predominant cause of zoonotic death prior to 1950; Lyme disease and West Nile fever since 2000. * Since 2010, reporting of “Rocky Mountain spotted fever” has been broadened to include                            related diseases –  under the heading “Spotted fever rickettsiosis”   Refer...
Source: GIDEON blog - Category: Databases & Libraries Authors: Tags: Ebooks Epidemiology Graphs ProMED Source Type: blogs
AbstractThe mass vaccination of dogs is a proven tool for rabies prevention. Besides parenteral delivery of inactivated vaccines, over the past several decades, several self-replicating biologics, including modified-live, attenuated and recombinant viruses, have been evaluated for the oral vaccination of dogs against rabies. Vaccines are included within an attractive bait for oral consumption by free-ranging dogs. Due to the high affinity between dogs and humans, such biologics intended for oral vaccination of dogs (OVD) need to be efficacious as well as safe. Baits should be preferentially attractive to dogs and not to no...
Source: Veterinary Research - Category: Veterinary Research Source Type: research
Conclusion: RIG-C was well tolerated and provided neutralizing rabies antibodies, which combined with vaccine series after rabies exposure, should result in effective prophylaxis per World Health Organization/Centers for Disease Control and Prevention guidelines. PMID: 29983597 [PubMed]
Source: Clinical Pharmacology: Advances and Applications - Category: Allergy & Immunology Tags: Clin Pharmacol Source Type: research
[Concord] The National Livestock and Animal Welfare, Rabies control Taskforce in collaboration with World Animal Protection are currently meeting Sierra Leone government Ministers of Health, Agriculture, Education and the Judiciary between 2nd - 6th July to come up with an action plan to implement the National Rabies Elimination Strategy launched in 2017 in Freetown.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
Publication date: Available online 30 June 2018Source: BiologicalsAuthor(s): Zejun Wang, Yan Sun, Xianfu Wu, Darin S. Carroll, Wenli Lv, Lei You, Yaqi Ji, Jinrong Shi, Jiaxin Yan, Gelin Xu, Shengli MengAbstractThe NIH potency test for human rabies vaccines has disadvantages for use, especially in developing countries where rabies is endemic and prophylaxis needs ample, rapid, and reliable vaccine supplies. In China, 60–75 million doses of human rabies vaccines are administered each year. Vaccine quality control is of paramount importance, as is the release of potency-validated vaccines. We intended to design an alter...
Source: Biologicals - Category: Biology Source Type: research
Publication date: Available online 2 May 2017Source: Pharmacology Biochemistry and BehaviorAuthor(s): Sachie K. Ogawa, Mitsuko Watabe-UchidaAbstractDopamine and serotonin play critical roles in flexible behaviors and are related to various psychiatric and motor disorders. This paper reviews the global organization of dopamine and serotonin systems through recent findings using a modified rabies virus. We first introduce methods for comprehensive mapping of monosynaptic inputs. We then describe quantitative comparisons across the data regarding monosynaptic inputs to dopamine neurons versus serotonin neurons. There is surpr...
Source: Pharmacology Biochemistry and Behavior - Category: Biochemistry Source Type: research
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