Brazilian teen becomes fifth person cured of rabies

Mateus dos Santos da Silva, from Rio Unini, contacted the virus last November. He had a pioneering treatment that saw him placed in an induced coma to protect his brain,
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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In this study we have generated several non-conform vaccine lots by an excessive inactivation with β-propiolactone (BPL) and assessed the capacity of both tests to detect the corresponding consequences. Excessive BPL inactivation causes G-protein unfolding, altering in turn viral morphology and the continuity of the G-protein layer in the viral particle. Both the NIH and the ELISA tests were able to monitor the consequences of excessive inactivation in a similar manner. Of note, the experimental error of the ELISA test was well below that of the NIH test. These results increase the prospect that the ELISA test could b...
Source: Biologicals - Category: Biology Source Type: research
RABIES was confirmed in a steer found in Larimer County, Colorado yesterday, prompting health officials to remind pet and livestock owners to keep their animals up-to-date on vaccinations. What are the symptoms of rabies and can you get rabies from a dog bite?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
This article will thus touch on three topics: First, how specific are the directional transmission patterns of these viruses? Second, what are the properties that confer synaptic specificity of viral transmission? Lastly, what can we learn from this specificity, and can we use it to devise better transsynaptic tracers?
Source: Journal of Chemical Neuroanatomy - Category: Neuroscience Source Type: research
Publication date: Available online 7 May 2019Source: Antiviral ResearchAuthor(s): Zoé Lama, Yves Gaudin, Danielle Blondel, Cécile Lagaudriere-GesbertAbstractRabies virus (RABV) is a neurotropic virus that causes fatal encephalitis in humans and animals and still kills up to 59,000 people worldwide every year. To date, only preventive or post-exposure vaccination protects against the disease but therapeutics are missing. After screening a library of 80 kinases inhibitors, we identified two compounds as potent inhibitors of RABV infection: Tyrphostin 9 and Rottlerin. Mechanism of action studies show that both i...
Source: Antiviral Therapy - Category: Virology Source Type: research
Abstract Rabies virus (RABV) is a neurotropic virus that causes fatal encephalitis in humans and animals and still kills up to 59,000 people worldwide every year. To date, only preventive or post-exposure vaccination protects against the disease but therapeutics are missing. After screening a library of 80 kinases inhibitors, we identified two compounds as potent inhibitors of RABV infection: Tyrphostin 9 and Rottlerin. Mechanism of action studies show that both inhibitors interfere with an early step of viral cycle and can prevent viral replication. In presence of Tyrphostin 9, the viral entry through endocytosis...
Source: Antiviral Research - Category: Virology Authors: Tags: Antiviral Res Source Type: research
Publication date: Available online 30 April 2019Source: Comparative Immunology, Microbiology and Infectious DiseasesAuthor(s): Diego Fontana, Federico Marsili, Ernesto Garay, Juan Battagliotti, Marina Etcheverrigaray, Ricardo Kratje, Claudio PrietoAbstractRabies is a neglected disease with an estimated annual mortality of 55,000 human deaths, affecting mainly low-income countries. Over 95% of these cases result from virus transmission through the bite of infected dogs and for this reason there is a real need for a cheap and effective rabies veterinary vaccine to be used in mass vaccination campaigns. In this work, we descr...
Source: Comparative Immunology, Microbiology and Infectious Diseases - Category: Infectious Diseases Source Type: research
A charmed (?) source for pharmaceuticals, ex-magician John A. Hamlin added the botanicals sassafras and cloves to a chloroform elixir that also contained turpentine, ammonia, and camphor. He then bottled it in Chicago (bottom left) as “Hamlins Wizard Oil.” This magical medicine was peddled as an external liniment and topical remedy for toothache and earache. Unfortunately, Hamlin also began encouraging internal use of his panacea as a cure for headache, diphtheria, pneumonia, rabies, and cancer. (Granted, the roughly 60% alco hol content may have provided imbibers with transient relief from their aches and pain...
Source: Anesthesiology - Category: Anesthesiology Source Type: research
ConclusionOur results indicate that the biases described by PT are present among public health professionals, which highlights the need to incorporate a PT framework when eliciting their preferences for surveillance systems.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
This study not only gives us insight into the understanding of the phenotype of RABV N gene rearrangement, but also helps with rabies vaccine candidate construction.
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
by Harish Kumar Tiwari, Ian D. Robertson, Mark O ’Dea, Abi Tamim Vanak Canine rabies is endemic in urban India. A questionnaire was administered to 204 residents of the urbanised municipality of Panchkula in north India to assess the influence of gender, age, family size, social status and dog ownership, over the knowledge, attitudes and practices (KAP) towards rabie s control and free-roaming dogs (FRD) in their locality. Bivariate analyses revealed significant knowledge gaps regarding crucial information on the control and transmission of rabies. Multivariable logistic regression models found that the respondents ...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
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