[Evaluation of the Safety of 2.0% Ganciclovir Eye Drops for Hospital Preparation].

[Evaluation of the Safety of 2.0% Ganciclovir Eye Drops for Hospital Preparation].
Yakugaku Zasshi. 2018;138(1):107-110
Authors: Nakagawa H, Matsumaru Y, Nose S, Sasaki H, Kitahara T
Abstract
 The concentration of ganciclovir eye drops for hospital preparation was changed from 0.5% to 2.0% at the Nagasaki University Hospital from March 2015. We investigated the incidence of side effects in 12 patients using 2.0% ganciclovir eye drops and evaluated the cytotoxicity of 2.0% ganciclovir eye drops using cultured rabbit corneal cells in vitro. As a side effect of 2.0% ganciclovir eye drops, three patients exhibited an early feeling of transient stimulation. The 2.0% ganciclovir eye drops did not demonstrate cell cytotoxicity for cultured corneal cells after 5 min, but did after 10 min. These findings suggested that the 2.0% ganciclovir eye drops can be used without corneal epithelium disorder in clinical settings.
PMID: 29311455 [PubMed - in process]

Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 11, 2018 Category: Drugs & Pharmacology Authors: Nakagawa H, Matsumaru Y, Nose S, Sasaki H, Kitahara T Tags: Yakugaku Zasshi Source Type: research