[Elaboration of Pseudo-natural Products Using Artificial In Vitro Biosynthesis Systems].
[Elaboration of Pseudo-natural Products Using Artificial In Vitro Biosynthesis Systems].
Yakugaku Zasshi. 2018;138(1):55-61
Authors: Goto Y
Abstract
Peptidic natural products often consist of not only proteinogenic building blocks but also unique non-proteinogenic structures such as macrocyclic scaffolds and N-methylated backbones. Since such non-proteinogenic structures are important structural motifs that contribute to diverse bioactivity, we have proposed that peptides with non-proteinogenic structures should be attractive candidates as artificial bioactive peptides mimicking natural products, or so-called pseudo-natural products. We previously devised an engineered translation system for pseudo-natural peptides, referred to as the flexible in vitro translation (FIT) system. This system enabled "one-pot" synthesis of highly diverse pseudo-natural peptide libraries, which can be rapidly screened by mRNA display technology for the discovery of pseudo-natural peptides with diverse bioactivities.
PMID: 29311466 [PubMed - in process]
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - Category: Drugs & Pharmacology Authors: Goto Y Tags: Yakugaku Zasshi Source Type: research