The Dynamic Actin Cytoskeleton in Smooth Muscle.

The Dynamic Actin Cytoskeleton in Smooth Muscle. Adv Pharmacol. 2018;81:1-38 Authors: Tang DD Abstract Smooth muscle contraction requires both myosin activation and actin cytoskeletal remodeling. Actin cytoskeletal reorganization facilitates smooth muscle contraction by promoting force transmission between the contractile unit and the extracellular matrix (ECM), and by enhancing intercellular mechanical transduction. Myosin may be viewed to serve as an "engine" for smooth muscle contraction whereas the actin cytoskeleton may function as a "transmission system" in smooth muscle. The actin cytoskeleton in smooth muscle also undergoes restructuring upon activation with growth factors or the ECM, which controls smooth muscle cell proliferation and migration. Abnormal smooth muscle contraction, cell proliferation, and motility contribute to the development of vascular and pulmonary diseases. A number of actin-regulatory proteins including protein kinases have been discovered to orchestrate actin dynamics in smooth muscle. In particular, Abelson tyrosine kinase (c-Abl) is an important molecule that controls actin dynamics, contraction, growth, and motility in smooth muscle. Moreover, c-Abl coordinates the regulation of blood pressure and contributes to the pathogenesis of airway hyperresponsiveness and vascular/airway remodeling in vivo. Thus, c-Abl may be a novel pharmacological target for the development of new therapy to treat smooth mus...
Source: Advances in Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Adv Pharmacol Source Type: research

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Conclusions: While the number of identified studies was not large, none reported negative impacts of mHealth on selected outcomes. Future studies on mHealth should design interventions with a greater variety of targeted functions and should adopt more rigorous methodologies to strengthen the evidence for its effectiveness in chronic disease management. PMID: 30109152 [PubMed]
Source: Healthcare Informatics Research - Category: Information Technology Tags: Healthc Inform Res Source Type: research
This case was written by one of ourgreat Hennepin 2nd year residents, Aaron Robinson, with lots of comments and edits by Smith.Thanks to Dr. Smith and Dr. Travis Olives for being part of this case. A 12 year old girl with a history of mild intermittent asthma presented to the emergency department with worsening shortness of breath over the past couple of days. She is up to date on her vaccinations and has no PMHx besides asthma and a noncontributory family history. She does not identify any specific triggers for her asthma. Initial screen in triage revealed normal vitals signs and a normal temperature. Upon interviewi...
Source: Dr. Smith's ECG Blog - Category: Cardiology Authors: Source Type: blogs
A 70-year-old lady presented to the dermatology clinic with a left shoulder lesion which did subsequently spread and involved both her buttock area. The lesions were asymptomatic most of time. Occasionally they became pruritic. She was otherwise well with a history of cystinuria, hypertension, asthma, pulmonary hypertension and brochiectasis for which she was on multiple medications including Thiola (tiopronin) tablets. On examination she had multiple annular lesions with a rim of erythema spread throughout her trunk.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research
A new research review has plenty of good news for people who love a good sauna session: Studies overwhelmingly suggest that the relaxing habit is also a healthy one. A paper published Wednesday in Mayo Clinic Proceedings gathered existing findings on Finnish sauna bathing, the practice of spending time in relatively dry rooms heated to between 80 and 100 degrees, interspersed with periods of cooling. The results were culled from more than 70 studies published up through February 2018. Overall, the research suggests that “sauna bathing, an activity used for the purposes of pleasure, wellness, and relaxation, is linked...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime onetime Research Source Type: news
Yesterday I came across a 2015 study that really caught my attention. A group of Norwegian researchers has discovered that the combination of dexamethasone with a natural compound called forskolin kills multiple myeloma cells. They tested forskolin with other conventional myeloma drugs, too: bortezomib (Velcade), cyclophosphamide, doxorubicin, and melphalan. And by itself. Results in a nutshell: dead myeloma cells.    Excerpt from the abstract: “Our findings support a potential role of forskolin in combination with current conventional agents in the treatment of MM.” The researchers believe that ...
Source: Margaret's Corner - Category: Cancer & Oncology Authors: Tags: Blogroll forskolin myeloma Source Type: blogs
The objective is to evaluate the impact of practice facilitation on chronic disease outcomes in the primary care setting.MethodsThis systematic review examined North American studies from PubMed, EMBASE, and Web of Science (database inception to August 2017). Investigators independently extracted and assessed the quality of the data on chronic disease process and clinical outcome measures. Studies implemented practice facilitation and reported quantifiable care processes and patient outcomes for chronic disease. Each study and their evidence were assessed for risk of bias and quality according to the Cochrane Collaboration...
Source: Journal of General Internal Medicine - Category: Internal Medicine Source Type: research
CONCLUSIONAND RELEVANCE: Comorbid CR is significantly associated with 30-day asthma- and COPD-related readmissions. These findings are useful for guiding healthcare professionals to focus on outpatient management of both the upper and lower respiratory tracts in order to reduce early readmission of asthma and COPD patients.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Abstract The aims of this study were to determine the prevalence of MRI abnormalities which were suspected as sinusitis in community-dwelling middle-aged and elderly Japanese and to identify risk factors for the MRI abnormality. Brain magnetic resonance imaging (MRI) data from the National Institute for Longevity Sciences, Longitudinal Study of Aging (NILS-LSA) were used for the analysis. Among the 2330 subjects in the NILS-LSA, 1933 participants were categorized as having no MRI abnormality or MRI abnormality using the Lund-Mackay (LM) score. The mean LM score of the participants was 0.88±1.92, and 144 (7....
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
TUESDAY, July 17, 2018 -- A new draft guideline from the U.S. Food and Drug Administration suggests Americans could get widely used prescription medicines for cholesterol, high blood pressure, asthma, and migraine headaches without having to see a...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
AbstractPurposeComorbidities associated with chronic obstructive pulmonary disease (COPD) affect quality of life and increase mortality. Asthma –COPD overlap (ACO) may express a different profile of comorbidities compared to COPD alone. It is unclear how recent changes in GOLD recommendations affect the profile of comorbidities in COPD and ACO.MethodsEight hundred and thirty-four patients with COPD were recruited from 67 Hungarian secondary care outpatient clinics, 469 of them had ACO. Comorbidities were defined by respiratory specialists based on medical history, patient report, and medications. COPD grades were def...
Source: Lung - Category: Respiratory Medicine Source Type: research
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