Survival in a cohort of patients with lung cancer: the role of age and gender in prognosis

ABSTRACT Objective: To determine the demographic and clinical characteristics of patients with non-small cell lung cancer (NSCLC), as well as their disease course, by age group and gender. Methods: This was a retrospective cohort study of patients diagnosed with NSCLC from 2000 to 2012 and followed until July 2015 in a tertiary referral hospital in the city of S ão Paulo, Brazil. Based on the 25th and 75th percentiles of the age distribution, patients were stratified into three age groups:
Source: Jornal Brasileiro de Pneumologia - Category: Respiratory Medicine Source Type: research

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In conclusion, apatinib shows some efficacy in heavily treated NSCLC and generally tolerable toxicity in non-squamous NSCLC. More solid evidence will be accessible in near future.
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
Authors: Shi A, Min W, Xiang L, Xu W, Jiang T Abstract The present study aimed to investigate the diagnostic value of automatic DNA image cytometry (DNA-ICM) for diagnosing lung cancer. A total of three different types of samples from 465 cases were included: Bronchoalveolar lavage fluid (BALF), 386 samples; pleural effusion cases, 70 samples; and fine-needle aspiration procedures, 9 samples. Two methods, liquid-based cytology (LBC) and automatic DNA-ICM, were used to assess the samples, and the pathological results of 120/465 cases were reviewed. The results of DNA-ICM were compared with those of LBC and pathology...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Lung cancer is one of the most common cancers and accounts for 26% of all cancer deaths [1]. There will be an estimated 222,500 new cases of lung cancer and approximately 155,870 associated deaths in the United States in 2017 [1]. Lung cancers are divided into non –small cell lung cancer (NSCLC; ∼80%-85%) and small cell lung cancer (SCLC; ∼10%-15%) [2]. Pathologically, NSCLC is further divided into adenocarcinoma (∼40%), squamous cell carcinoma (SCC; ∼25%-30%), and large cell carcinoma (∼10%-15%) [2].
Source: Cancer Treatment Reviews - Category: Cancer & Oncology Authors: Tags: Anti-Tumour Treatment Source Type: research
In conclusion, high PINK1 expression is correlated with poor response to chemotherapy and is an independent prognostic factor for AC, but not for SCC. Our findings suggest that PINK1 detection could help stratify patients who may have poor response to chemotherapy and guide the individual treatment. PMID: 29937472 [PubMed - in process]
Source: The Tohoku Journal of Experimental Medicine - Category: Research Authors: Tags: Tohoku J Exp Med Source Type: research
Lung cancer is considered one of the leading causes of death due to cancer worldwide [1]. The classification of lung cancer is based on histologic characteristics, and it is mainly divided into two subtypes: non-small cell lung cancer (NSCLC), which is responsible for 85% of lung cancer cases, and small cell lung cancer (SCLC) [1]. NSCLC is further subdivided into adenocarcinoma, squamous cell carcinoma, and large cell carcinoma [1,2]. Although most lung cancers are classified as either NSCLC or SCLC and probably remain as such, the development of safer biopsy methods has allowed more frequent repeat biopsies, which someti...
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
Lung cancer (LC) is the leading cause of cancer-related mortality worldwide, accounting for 1.69 million out of the total of 8.8 million cancer-related deaths in 2015 [1]. Non-small cell lung carcinoma (NSCLC) is involved in up to 90% of LC cases, with adenocarcinoma (ADC) and squamous cell carcinoma (SCC) being the major subtypes [2]. Unfortunately, almost 85% of patients with LC remain undiagnosed until the disease is symptomatic and has reached an advanced stage [3], resulting in poor prognosis and an overall 5 ‑year survival rate of less than 15% [4,5].
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
AbstractBackgroundThe clinical efficacy observed with inhibitors of programed cell death 1/programed cell death ligand 1 (PD-L1/PD-1) in cancer therapy has prompted studies to characterize the immune response in several tumor types, including lung cancer. However, the immunological profile of non –small cell lung carcinoma (NSCLC) treated with neoadjuvant chemotherapy (NCT) is not yet fully characterized, and it may be therapeutically important. The aim of this retrospective study was to characterize and quantify PD-L1/PD-1 expression and tumor-associated immune cells (TAICs) in surgically resected NSCLCs from patien...
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research
ConclusionsA unique radiomic signature was constructed for use as a diagnostic factor for discriminating lung ADC from SCC. Patients with NSCLC will benefit from the proposed radiomic signature.Key points• Machine learning can be used for auxiliary distinguish in lung cancer.• Radiomic signature can discriminate lung ADC from SCC.• Radiomics can help to achieve precision medical treatment.
Source: European Radiology - Category: Radiology Source Type: research
Authors: Jiang D, Shi J, Yuan M, Duan X, Li L, Li Q Abstract Elevated bilirubin has been associated with protection of cardiovascular and kidney systems, whereas decreased bilirubin may predispose respiratory diseases. However, whether serum bilirubin levels are associated with lung cancer remains unclear. Here, clinical and pathologic data of a cohort of 363 lung cancer patients along with 363 age-and gender-matched healthy subjects were collected. The association of serum bilirubin levels with lung cancer was analyzed. The levels of serum bilirubin were significantly lower in lung cancer patients. The aspartate t...
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research
In this study, we performed RNA-seq in platelets from 7 healthy individuals and 15 non-small cell lung cancer (NSCLC) patients. Our data revealed a subset of near universal differently expressed gene (DEG) profiles in platelets of metastatic NSCLC compared to healthy individuals, including 626 up-regulated RNAs (mRNAs and ncRNAs) and 1497 down-regulated genes. The significant over-expressed genes showed enrichment in focal adhesion, platelets activation, gap junction and adherens junction pathways. The DEGs also included previously reported tumor-related genes such as PDGFR, VEGF, EGF, etc., verifying the consistence and s...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
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