Survival in a cohort of patients with lung cancer: the role of age and gender in prognosis

ABSTRACT Objective: To determine the demographic and clinical characteristics of patients with non-small cell lung cancer (NSCLC), as well as their disease course, by age group and gender. Methods: This was a retrospective cohort study of patients diagnosed with NSCLC from 2000 to 2012 and followed until July 2015 in a tertiary referral hospital in the city of S ão Paulo, Brazil. Based on the 25th and 75th percentiles of the age distribution, patients were stratified into three age groups:
Source: Jornal Brasileiro de Pneumologia - Category: Respiratory Medicine Source Type: research

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(International Association for the Study of Lung Cancer) Patients with metastatic NSCLC receiving treatment at academic centers (ACs) have an increased 2-year survival compared to patients treated at community-based centers (CCs). An overall histology-dependent survival was also noted in patients with adenocarcinoma verses squamous cell carcinoma and varied by treatment facility.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
ConclusionThese findings suggested that PITX1 might serve as a potential biomarker for early detection and prognosis prediction of LUAD patients.
Source: Pathology Research and Practice - Category: Pathology Source Type: research
ConclusionConsidering the results of our research and the literature review we made sure that VATS lobectomy with mediastinal lymph node dissection is an alternative procedure to open approaches: it is much safer, reduce the frequency of post-operative complications and the rehabilitation period. We believe that complete VATS lobectomy with mediastinal lymph node dissection must be taken as a standard in surgical treatment of patients with early stages of non-small cell lung cancer.
Source: Annals of Medicine and Surgery - Category: General Medicine Source Type: research
CONCLUSION: PD-L1-positive tumors were frequent in acinar predominant adenocarcinoma and solid predominant adenocarcinoma than other adenocarcinoma subtypes. PD-L1 expression seemed to increase according to pathologic tumor progression, suggesting a worse postoperative prognosis in NSCLC patients. PMID: 30282880 [PubMed - as supplied by publisher]
Source: Annals of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Cardiovasc Surg Source Type: research
ConclusionCXCR4 may be a promising target for diagnostics and therapy in both SCLC and NSCLC.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
Lung cancer is the leading cause of cancer-related deaths worldwide (1). The main types of lung cancer are small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), accounting for 15% and 85% of the established cases respectively. NSCLC can be subdivided into two major subtypes: squamous cell carcinoma (SCC) and adenocarcinoma (AC), which differ in clinical, radiological, and histological characteristics (2). The diagnosis of early-stage lung cancer is crucial for succesful curative therapy, because treatment options and prognosis directly depend on tumour size and metastatic spread at the time of diagnosis (3).
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
In conclusion, these results indicated that comprehensive analysis of marker gene detection and CT results may be used to diagnose human lung cancer. PMID: 30250539 [PubMed]
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
ConclusionCXCR4 may be a promising target for diagnostics and therapy in both SCLC and NSCLC.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
Authors: Ma W, Wang M, Li X, Huang H, Zhu Y, Song X, Dai D, Xu W Abstract The aim of the present study was to investigate the prognostic value of quantitative [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) parameters for patients with non-small cell lung cancer (NSCLC). The present study conducted a retrospective review of the medical records of 203 patients with NSCLC, of which 193 patients underwent baseline 18F-FDG PET/CT prior to initial therapy. Multivariate analyses using Cox's proportional hazards regression were performed for the assessment of the association betwe...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
In conclusion, the findings from this study suggest that increase in MRP1 gene expression is associated with being a non‑smoker, adenocarcinoma, advanced clinical stages and a poor response to chemotherapy in patients with NSCLC. The results from the most extensive and updated data on MRP1 support the requirement for continued investigation into the potential use of MRP1 as a biomarker/clinical indicator for NSCLC. PMID: 30132569 [PubMed - as supplied by publisher]
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
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