A stereospecific carboxyl esterase from Bacillus  coagulans hosting nonlipase activity within a lipase‐like fold

We report the high‐resolution crystal structure of a carboxylesterase from Bacillus coagulans with lipase‐like structural features, despite nonlipolytic‐like catalytic activities. This enzyme is of particular interest due its enantioselectivity for (S)‐1,2‐O‐isopropylidenglycerol (IPG) esters and activity at elevated temperatures; (S)‐IPG is an important building block for a number of compounds, including pharmaceuticals, implying a potential use for biocatalysis.

Source: FEBS Journal - January 11, 2018 Category: Research Authors: Valerio De Vitis, Cristina Nakhnoukh, Andrea Pinto, Martina L. Contente, Alberto Barbiroli, Mario Milani, Martino Bolognesi, Francesco Molinari, Louise J. Gourlay, Diego Romano Tags: Original Article Source Type: research