The role of Nrf2 signaling in counteracting neurodegenerative diseases

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Source: FEBS Journal - Category: Research Authors: Tags: Review Article Source Type: research

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In conclusion, the method we describe here can be used to study DSB repair mechanisms, with direct utility for molecularly optimising the knock-out/in outcomes in genome manipulation. PMID: 30017059 [PubMed - in process]
Source: DNA Repair - Category: Genetics & Stem Cells Authors: Tags: DNA Repair (Amst) Source Type: research
Alzheimer's and Other Dementias
Source: Clinics in Geriatric Medicine - Category: Geriatrics Source Type: research
Researchers have found that changes in PET scans of military personnel with...Read more on AuntMinnie.comRelated Reading: Did PET scan confirm CTE in living NFL player? MRI shows promise in diagnosing CTE in living patients FDDNP-PET gives insight into brain trauma of NFL players FDDNP-PET shows toll of concussions on retired NFL players FDDNP-PET helps predict Alzheimer's progression
Source: Headlines - Category: Radiology Source Type: news
Conclusion: SIRT1 helps to regulate alternative splicing, which itself affects the DDR of NSCs. Our findings provide novel insight into the mechanisms underlying the DDR in stem cells.Cell Physiol Biochem 2018;48:657 –669
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
Early intervention to treat sleep disorders such as obstructive sleep apnea may help prevent or delay Alzheimer’s disease.
Source: ENT Today - Category: ENT & OMF Authors: Tags: Online Exclusives Practice Focus Sleep Medicine alzheimer's disease Source Type: research
Publication date: Available online 18 July 2018Source: Life SciencesAuthor(s): Monika M. GolasAbstractThe loss of gamma-aminobutyric acid (GABA)-ergic medium spiny neurons (MSNs) in the striatum is the hallmark of Huntington disease (HD), an incurable neurodegenerative disorder characterized by progressive motor, psychiatric, and cognitive symptoms. Transplantation of MSNs or their precursors represents a promising treatment strategy for HD. In initial clinical trials in which HD patients received fetal neurografts directly into the striatum without a pretransplant cell-differentiation step, some patients exhibited tempora...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 18 July 2018Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Miyu Nishikawa, Kaori Yasuda, Masashi Takamatsu, Keisuke Abe, Kimie Nakagawa, Naoko Tsugawa, Yoshihisa Hirota, Kazuma Tanaka, Shigeaki Yamashita, Shinichi Ikushiro, Tatsuo Suda, Toshio Okano, Toshiyuki SakakiAbstractWe have reported that 25-hydroxyvitamin D3 [25(OH)D3] binds to vitamin D receptor and exhibits several biological functions directly in vitro. To evaluate the direct effect of 25(OH)D3 in vivo, we used Cyp27b1 knockout (KO) mice, which had no detectable plasma 1α,25-dihydroxyvitamin D...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
INTRODUCTION: Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) are risk factors for early onset of Alzheimer's disease (AD) and may accelerate the progression rate of AD pathology. As amyloid-beta (A β) plaques are a hallmark of AD pa...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
AbstractIn patients with aortic regurgitation (AR), a precise preoperative assessment of aortic valve (AV) pathology is important if AV repair or sparing operation is an alternative option. The aim of this study was to assess the diagnostic accuracy of computed tomography (CT) for evaluating the AR mechanism compared with surgical inspection. 59 patients with AR who underwent AV surgery and preoperative cardiac CT were evaluated. AR mechanism was classified into type 1 (aortic dilatation or cusp perforation), type 2 (prolapsed cusp) and type 3 (cusp retraction). Agreement between CT and surgical inspection was obtained. Co...
Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research
Source: Acta Neurologica Belgica - Category: Neurology Source Type: research
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