Dual IRE1 RNase functions dictate glioblastoma development.

This study provides the first demonstration of a dual role of IRE1 downstream signaling in cancer and opens a new therapeutic window to abrogate tumor progression.
PMID: 29311133 [PubMed - as supplied by publisher]

Source: Molecular Medicine - January 8, 2018 Category: Molecular Biology Authors: Lhomond S, Avril T, Dejeans N, Voutetakis K, Doultsinos D, McMahon M, Pineau R, Obacz J, Papadodima O, Jouan F, Bourien H, Logotheti M, Jégou G, Pallares-Lupon N, Schmit K, Le Reste PJ, Etcheverry A, Mosser J, Barroso K, Vauléon E, Maurel M, Samali A, P Tags: EMBO Mol Med Source Type: research