Discovery of N-(3-Carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-2-yl)-lH-pyrazole-5-carboxamide (GLPG1837), a Novel Potentiator Which Can Open Class III Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channels to a High Extent

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.7b01288

Source: Journal of Medicinal Chemistry - January 10, 2018 Category: Chemistry Authors: Steven E. Van der Plas, Hans Kelgtermans, Tom De Munck, Se ́bastien L. X. Martina, Sébastien Dropsit, Evelyne Quinton, Ann De Blieck, Caroline Joannesse, Linda Tomaskovic, Mia Jans, Thierry Christophe, Ellen van der Aar, Monica Borgonovi, Luc Nelles, M Source Type: research