Dr. Helen Genova awarded grant for novel emotional processing study in multiple sclerosis

(Kessler Foundation) Helen Genova, Ph.D., Assistant Director of Neuropsychology&Neuroscience Research at Kessler Foundation, has been awarded a $44,000 grant from the National Multiple Sclerosis Society. The grant funds her research on emotional processing deficits in people with multiple sclerosis, an autoimmune degenerative disease of the central nervous system associated with significant behavioral and emotional sequelae.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Semin Neurol 2018; 38: 278-289 DOI: 10.1055/s-0038-1660856Prompt recognition of an inflammatory myelopathy is critical, as a specific diagnosis and management plan allows for optimal patient outcomes. Many treatment options are now available for autoimmune and paraneoplastic myelopathies, but specific management strategies and expected prognosis vary widely depending on the underlying etiology. An understanding of the relevant clinical details, imaging findings, and other diagnostic information that can help achieve a specific myelopathy diagnosis and treatment plan is essential for all neurologists, given the variety of c...
Source: Seminars in Neurology - Category: Neurology Authors: Tags: Review Article Source Type: research
Authors: Kattimani Y, Veerappa AM Abstract Multiple sclerosis (MS) is a demyelinating disease of the central nervous system causing axonal injury, neuronal loss, and atrophy of the central nervous system leading to permanent neurological and clinical disability. Presence of mutations in M9 domain of HNRNPA1 and detection of autoantibodies against this domain in HNRNPA1 qualifies it as a strong candidate for causing MS. These two aspects indicate the presence of a facilitator in associating them. Varicella zoster virus (VZV), known to cause chicken pox infection in humans, is a significant contender in sensitizing t...
Source: Autoimmunity - Category: Allergy & Immunology Tags: Autoimmunity Source Type: research
Conclusions Our case of GFAPα IgG-associated encephalitis along with 12 other cases of serious inflammatory brain disorders following daclizumab treatment so far indicates that interfering with NK cells and Tregs by anti-CD25 antibody therapy can result in severe secondary CNS autoimmunity in man.
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: Autoimmune diseases, Multiple sclerosis Article Source Type: research
Multiple sclerosis (MS) is an inflammatory and neurodegenerative autoimmune demyelinating disease of the central nervous system. Patients exhibit heterogeneous patterns of disabling symptoms, including spasticity. In the majority of patients with MS spasticity, it and its associated symptoms contribute to disability, interfere with performance of everyday activities, and impair quality of life. Even under treatment with oral antispasticity drugs, about a third of patients continue to experience spasticity of moderate to severe intensity, underscoring the need for additional treatment options. The efficacy of tetrahydrocann...
Source: Case Reports in Neurology - Category: Neurology Source Type: research
Publication date: Available online 10 July 2018Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Nikita A. Mitkin, Alisa M. Muratova, Kirill V. Korneev, Vsevolod V. Pavshintsev, Konstantin A. Rumyantsev, Murad S. Vagida, Aksinya N. Uvarova, Marina A. Afanasyeva, Anton M. Schwartz, Dmitry V. KuprashAbstractCD58 is expressed on the surface of antigen-presenting cells, including B-cells, and provides co-stimulation to regulatory T-cells (Treg) through CD2 receptor binding. Tregs appear to be essential suppressors of tissue-specific autoimmune responses. Thereby, CD58 plays protective role in m...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
A new study has raised the possibility that stress may cause autoimmune disease, such as lupus or rheumatoid arthritis, because it found a higher incidence of autoimmune diseases among people who were previously diagnosed with stress-related disorders. I have patients who heard about this research and are saying, “I knew it!” But before we accept a potential link between stress and autoimmune disease, let’s look at some details of the study and consider how we define the terms “autoimmune disease,” “stress,” and “stress-related disorder.” What is autoimmune disease? The...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Autoimmune diseases Health Stress Source Type: blogs
Publication date: 2018Source: NeuroImage: Clinical, Volume 19Author(s): Joseph Kuchling, Yael Backner, Frederike C. Oertel, Noa Raz, Judith Bellmann-Strobl, Klemens Ruprecht, Friedemann Paul, Netta Levin, Alexander U. Brandt, Michael ScheelAbstractBackgroundDiffusion Tensor Imaging (DTI) can evaluate microstructural tissue damage in the optic radiation (OR) of patients with clinically isolated syndrome (CIS), early relapsing-remitting multiple sclerosis and neuromyelitis optica spectrum disorders (NMOSD). Different post-processing techniques, e.g. tract-based spatial statistics (TBSS) and probabilistic tractography, exist ...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Publication date: July 2018Source: Joint Bone Spine, Volume 85, Issue 4Author(s): Johanna Sigaux, Luca Semerano, Guillaume Favre, Natacha Bessis, Marie-Christophe BoissierAbstractSalt is a vital nutrient. Excess salt intake, however, has recently been blamed for triggering and/or worsening certain autoimmune diseases. In vitro, the cells involved in innate and adaptive immune responses exhibit an inflammatory profile when placed in hypertonic saline. More specifically, macrophages release increased amounts of proinflammatory cytokines, produce reactive oxygen species, and become capable of activating the inflammasome. T he...
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
We report herein the case of a 38-year old woman, with the rare co-existence of DM2 and MS and argue about the challenging differential diagnosis if CNS involvement is present in DM2 patients. Thus, is it another expression of a multisystem disorder or an unfortunate pure coincidence?
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 4 July 2018Source: Multiple Sclerosis and Related DisordersAuthor(s): Patrick K A Kearns, Helen A Casey, John Paul LeachAbstractMultiple Sclerosis is a chronic, progressive and debilitating neurological disease which, despite extensive study for over 100 years, remains of enigmatic aetiology. Drawn from the epidemiological evidence, there exists a consensus that there are environmental (possibly infectious) factors that contribute to disease pathogenesis that have not yet been fully elucidated. Here we propose a three-tiered hypothesis: 1) a clinic-epidemiological model of multiple sclero...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
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