Dr. Helen Genova awarded grant for novel emotional processing study in multiple sclerosis
(Kessler Foundation) Helen Genova, Ph.D., Assistant Director of Neuropsychology&Neuroscience Research at Kessler Foundation, has been awarded a $44,000 grant from the National Multiple Sclerosis Society. The grant funds her research on emotional processing deficits in people with multiple sclerosis, an autoimmune degenerative disease of the central nervous system associated with significant behavioral and emotional sequelae.
Pemphigus vulgaris (PV) is a potentially fatal blistering disease caused by autoantibodies to desmoglein 3 (Dsg3). Several autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, and myasthenia gravis, have defective central and/or peripheral B cell tolerance checkpoints, leading to an accumulation of polyreactive B cells that is thought to provide the first hit toward the development of autoimmunity. We investigated whether PV patients have intact tolerance checkpoints to self-antigens other than Dsg3, which would differentiate the mechanism of autoimmunity in PV from those of other autoimmune diseases.
A compound from immune cells treats psoriasis in mice and might also be effective in treating multiple sclerosis, rheumatoid arthritis and lupus.
We presented positive initial results in Crohn’s disease at the 2016 United European Gastroenterology meeting: six of the eight patients had seen a substantial reduction in their disease activity index scores, and three were in remission from the disease. As SetPoint looks ahead, several chronic disease areas are emerging as key bioelectronic medicine therapy targets, and our company is exploring a number of these. One of our preclinical programs explores bioelectronic medicine’s potential role as a treatment for MS. New Target: Multiple Sclerosis In late 2017, SetPoint presented positive data from a s...
Phase I data show early efficacy in the majority of patients and a very favourable safety profile HASSELT, Belgium and CHEPSTOW, Wales, April 16, 2018 -- (Healthcare Sales &Marketing Network) -- Apitope, a clinical stage biotech company developing pot... Biopharmaceuticals Apitope, Graves' Disease, Multiple Sclerosis, autoimmune disease
Publication date: May 2018 Source:Neurochemistry International, Volume 115 Author(s): Zhihui Zhu, Georg Reiser Small heat shock proteins (sHsps) are a group of proteins with molecular mass between 12 and 43 kDa. Currently, 11 members of this family have been classified, namely HspB1 to HspB11. HspB1, HspB2, HspB5, HspB6, HspB7, and HspB8, which are expressed in brain have been observed to be related to the pathology of neurodegenerative diseases, including Parkinson's, Alzheimer's, Alexander's disease, multiple sclerosis, and human immunodeficiency virus-associated dementia. Specifically, sHsps interact with misfolding ...
Progressive multifocal leukoencephalopathy (PML), first described in 1959, is an often-fatal disease caused by an opportunistic infection by JC virus (JCV), which most human beings carry throughout life without consequences.1,2 PML was a major cause of death in patients with AIDS, but its prevalence decreased sharply with the introduction of retroviral therapy. PML is now mostly seen in patients during chemotherapy or immunosuppression. The first PML cases in patients with multiple sclerosis who were treated with natalizumab came as a surprise in 20053,4 because PML had not been observed with other drugs for multiple scler...
Conclusion OCT detected GCC changes in EAE may resemble what is observed in MS-related acute ON: an initial phase of swelling (indicative of inflammatory edema) followed by a decrease in thickness over time (representative of neuro-axonal degeneration). In line with OCT findings, DTI of the visual pathway identifies EAE induced pathology (decreased AD, and increased RD). Immunofluorescence analysis provides support for inflammatory pathology and axonal degeneration. OCT together with DTI can detect retinal and optic nerve damage and elucidate to the temporal sequence of neurodegeneration in this rodent model of MS in vivo.
This article is protected by copyright. All rights reserved. PMID: 29637999 [PubMed - as supplied by publisher]
CONCLUSIONS: We found that the prevalence of MS was more than two fold higher in Karabük than in Akçakoca, which supports a link between air pollution and the pathogenesis of MS. However, larger etiological and epidemiological studies are needed to confirm this hypothesis. PMID: 29629528 [PubMed]
Macrophage migration inhibitory factor (MIF) is a cytokine associated with tissue damage in multiple autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis and psoriatic arthritis. The role of MIF in multiple sclerosis (MS) and the contribution of its polymorphisms are unknown in our population. Therefore, we decided to investigate the genetic association of -794 CATT5-8 (rs5844572) and -173 G>C (rs755622) MIF polymorphisms with MS, clinical variables and MIF serum levels in the population of western Mexico.