Posaconazole Pharmacokinetics in Adults with Invasive Fungal Infections
Posaconazole Pharmacokinetics in Adults with Invasive Fungal InfectionsWed, 01/03/2018 - 15:39News blog
Fungus-specific CD4 T Cells as Specific Sensors for Pulmonary Fungal Infections&SensitizationThursday, February 15, 2018 - 10:46Slide presentation
Airflow obstruction infection and inflammation are key components of respiratory morbidity in patients with cystic fibrosis (CF). Chronic respiratory fungal infections, most commonly with moulds of the genera Aspergillus and Exophiala, are common in this patient cohort. An increased susceptibility to fungal infections may be observed in individuals with defects in IL-17RA signalling pathways, a situation characterised by excessive mucus production, increased Th2 cytokine, IL-17F, IL-33 and reduced IFN- γ secretion in patients without CF .
Abstract Aspergillus fumigatus is an opportunistic pathogen, the leading cause of invasive and disseminated aspergillosis in systemic immunocompromised patients, and an important cause of mortality. The aim of the present study was to adapt a pulmonary aspergillosis murine model, to determine pathodynamical parameters quantitatively, and to follow the progression of fungal infection in vivo. The nasal inoculation of Aspergillus conidia in mice previously subjected to immunosuppression with cyclophosphamide (CP) turned out to be a more suitable model than that of immunosuppressed with hydrocortisone (HC). The follo...
CONCLUSION: Results from this study recommends that plant rhizosphere remains a rich hotspot for delivering a novel antifungal compounds. PMID: 29412110 [PubMed - as supplied by publisher]
Cryptococcus neoformans (wikipedia.org) 2.5 out of 5 stars Cryptococcal meningitis in a daily cannabis smoker without evidence of immunodeficiency. Shapiro BB et al. BMJ Case Rep 2018 Jan 26 [Epub ahead of print] Abstract Can smoking marijuana cause meningitis? The question is not unreasonable. A wide range of pathogenic fungi — including Aspergillus and various Cryptococcus species — have been isolated from dispensary-grade medical marijuana samples. Concern that these pathogens could cause pneumonia or central nervous system infections has focussed on those with immunodeficiency, such...
Background/purpose: Prevention of invasive fungal infections is critical for SCT patients. The potential of echinocandins as prophylaxis may be limited by the dosing of current agents. CD101 is a novel echinocandin, currently in Phase 2 study for once weekly treatment of candidemia and invasive candidiasis. Clinical pharmacokinetics of CD101 were compared to measures of nonclinical in vitro susceptibility and/or in vivo efficacy to guide dose selection for prevention of fungal infections.
Conclusions: Categorizing hyphae into the three groups described allows pathologists to provide information that is useful for infectious disease treatment with an inclusive differential diagnosis of diverse fungal genera that share the same morphological features. PMID: 29365030 [PubMed - as supplied by publisher]
l W Abstract Echinocandins are antifungal nonribosomal hexapeptides produced by fungi. Two of the amino acids are hydroxy-l-prolines: trans-4-hydroxy-l-proline and, in most echinocandin structures, (trans-2,3)-3-hydroxy-(trans-2,4)-4-methyl-l-proline. In the case of echinocandin biosynthesis by Glarea lozoyensis, both amino acids are found in pneumocandin A0, while in pneumocandin B0 the latter residue is substituted by trans-3- hydroxy-l-proline (3-Hyp). We have recently reported that all three amino acids are generated by the 2-oxoglutarate-dependent proline hydroxylase GloF. In echinocandin B biosynthesis by As...
This article is protected by copyright. All rights reserved. PMID: 29315506 [PubMed - as supplied by publisher]
Wed, 01/03/2018 - 15:39News blog