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Aberrant accumulation of ErbB4 in progressive supranuclear palsy

ConclusionsOur present results suggest that NRG1/ErbB4 signalling could be an important event in the pathogenesis of PSPThis article is protected by copyright. All rights reserved.
Source: Neuropathology and Applied Neurobiology - Category: Neurology Authors: Tags: Original Article Source Type: research

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The American Association of Nursing was established in 1968 to support and advance the art and science of neuroscience nursing. During the course of 50 years, the Journal of Neuroscience Nursing has published numerous articles detailing the advances in the treatments of neurologic disease. The following highlights the strides achieved in the management of Parkinson disease, neuromuscular disease, and multiple sclerosis (MS).
Source: Journal of Neuroscience Nursing - Category: Neuroscience Tags: Literature Review Source Type: research
DEMENTIA symptoms include memory loss and sudden mood changes. Eating a high-salt diet could be causing Alzheimer ’s disease and other brain conditions, scientists have now revealed.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Reduced levels of a mitochondrial enzyme were previously thought to destroy neurons in Parkinson's disease. The opposite may, in fact, be the case.
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Parkinson's Disease Source Type: news
Phosphorylated α-Synuclein-Copper Complex Formation in the Pathogenesis of Parkinson's Disease. Parkinsons Dis. 2017;2017:9164754 Authors: Castillo-Gonzalez JA, Loera-Arias MJ, Saucedo-Cardenas O, Montes-de-Oca-Luna R, Garcia-Garcia A, Rodriguez-Rocha H Abstract Parkinson's disease is the second most important neurodegenerative disorder worldwide. It is characterized by the presence of Lewy bodies, which are mainly composed of α-synuclein and ubiquitin-bound proteins. Both the ubiquitin proteasome system (UPS) and autophagy-lysosomal pathway (ALS) are altered in Parkinson's disease, leading...
Source: Parkinsons Disease - Category: Neurology Tags: Parkinsons Dis Source Type: research
Impact of Mézières Rehabilitative Method in Patients with Parkinson's Disease: A Randomized Controlled Trial. Parkinsons Dis. 2017;2017:2762987 Authors: Paolucci T, Zangrando F, Piccinini G, Deidda L, Basile R, Bruno E, Buzi E, Mannocci A, Tirinelli F, Haggiag S, Lispi L, Villani C, Saraceni VM Abstract The aim of this study was to assess the efficacy of Mézières method in improving trunk flexibility of the back muscles and balance in patients with Parkinson's disease (PD). Materials and Methods. Thirty-six patients were randomized into 2 groups: the Mézières t...
Source: Parkinsons Disease - Category: Neurology Tags: Parkinsons Dis Source Type: research
Authors: Dale W, Kotwal AA, Shega JW, Schumm LP, Kern DW, Pinto JM, Pudelek KM, Waite LJ, McClintock MK Abstract BACKGROUND: The Montreal Cognitive Assessment (MoCA) has not been administered to a representative national sample, precluding comparison of patient scores to the general population and for risk factor identification. METHODS: A validated survey-based adaptation of the MoCA (MoCA-SA) was administered to a probability sample of home-dwelling US adults aged 62 to 90, using the National Social Life, Health, and Aging Project (n=3129), yielding estimates of prevalence in the United States. The associatio...
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
CONCLUSION: This evidence-based approach might provide guidance to clinicians and nuclear medicine physicians to interpret amyloid-β PET results for early and differential diagnosis of patients with progressive cognitive impairment. PMID: 29334498 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
Authors: Gwon SY, Rhee KJ, Sung HJ Abstract The risk of rheumatoid arthritis (RA), an autoimmune disease, in the elderly population increases along with that of atherosclerosis, cardiovascular disease, type 2 diabetes, and Alzheimer's disease. Identifying specific biomarkers for RA can clarify the underlying molecular mechanisms and can aid diagnosis and patient care. To this end, the present study investigated the genes and proteins that are differentially expressed in RA using a mouse collagen-induced arthritis (CIA) model. We performed gene microarray and proteome array analyses using blood samples from the mice...
Source: International Journal of Medical Sciences - Category: Biomedical Science Tags: Int J Med Sci Source Type: research
Conclusions The decrease in functional connectivity between sensory and motor cortices, despite an increase in local spectral power, suggests that propofol causes a functional disconnection of cortices with increases in autonomous activity within cortical regions. This pattern occurs across diseases evaluated, suggesting that these may be generalizable effects of propofol in patients with movement disorders and beyond. Sensorimotor network disruption may underlie anesthetic-induced loss of volitional control.
Source: Anesthesiology - Category: Anesthesiology Source Type: research
Traynor BJ, Chia R, Chung SJ, International Parkinson's Disease Genomics Consortium (IPDGC), COURAGE-PD Consortium, Hardy JA, Brice A, Wood NW, Houlden H, Shulman JM, Morris HR, Gasser T, Krüger R, Heutink P, Sharma M, Simón-Sánchez J, Nalls MA, Singleton AB, Scholz SW Abstract Genetics has proven to be a powerful approach in neurodegenerative diseases research, resulting in the identification of numerous causal and risk variants. Previously, we introduced the NeuroX Illumina genotyping array, a fast and efficient genotyping platform designed for the investigation of genetic variation in neurode...
Source: Neurobiology of Aging - Category: Geriatrics Authors: Tags: Neurobiol Aging Source Type: research
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