Aberrant accumulation of ErbB4 in progressive supranuclear palsy

ConclusionsOur present results suggest that NRG1/ErbB4 signalling could be an important event in the pathogenesis of PSPThis article is protected by copyright. All rights reserved.
Source: Neuropathology and Applied Neurobiology - Category: Neurology Authors: Tags: Original Article Source Type: research

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Authors: Mumic de Melo L, Hotta Ansai J, Giusti Rossi P, Carvalho Vale FA, Cristhine de Medeiros Takahashi A, Pires de Andrade L Abstract In clinical practice, older people with cognitive impairment may have difficulties to understand the instructions of the Timed Up-and-Go (TUGT) test and present a bad performance. The purpose of this study was to identify differences in the TUGT performance, in an adapted version, between older adults with preserved cognition (PC), mild cognitive impairment (MCI) and Alzheimer's disease (AD), and to identify the association between the adapted TUGT performance and cognition among...
Source: Journal of Motor Behavior - Category: Neurology Tags: J Mot Behav Source Type: research
AbstractExcitotoxicity consists in a cascade of intracellular events initiated by an excessive release of glutamate and hyperactivation of glutamatergic receptors that is involved in several pathologies, including traumatic brain injury and neurodegenerative diseases such as Parkinson ’s disease. Both disorders are a common cause of olfactory dysfunction. We previously reported a role for glutamate excitotoxicity in olfactory dysfunction showing an olfactory deficit 1 week after lesion and a spontaneous recovery 2 weeks after excitotoxicity lesion of the olfactory bulbs (OBs) . The olfactory dysfunction rec...
Source: Molecular Neurobiology - Category: Neurology Source Type: research
AbstractDopamine has emerged as a fundamental regulator of inflammation. In this regard, it has been shown that dopaminergic signalling pathways are key players promoting homeostasis between the central nervous system and the immune system. Dysregulation in the dopaminergic system affects both innate and adaptive immunity, contributing to the development of numerous autoimmune and inflammatory pathologies. This makes dopamine receptors interesting therapeutic targets for either the development of new treatments or repurposing of already available pharmacological drugs. Dopamine receptors are broadly expressed on different ...
Source: Journal of NeuroImmune Pharmacology - Category: Drugs & Pharmacology Source Type: research
A common gut bacteria can block a common Parkinson's disease medicine from working on patients with the disease, a new study says.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
Different subtypes of Parkinson's disease have been proposed that accurately predict prognosis, disability, and survival and may eventually lead to the development of more specific treatments.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news
Publication date: Available online 17 January 2019Source: The Lancet NeurologyAuthor(s): Michael R Irwin, Michael V VitielloSummaryNearly half of all adults older than 60 years of age report sleep disturbance, as characterised either by reports of insomnia complaints with daytime consequences, dissatisfaction with sleep quality or quantity, or the diagnosis of insomnia disorder. Accumulating evidence shows that sleep disturbance contributes to cognitive decline and might also increase the risk of Alzheimer's disease dementia by increasing β-amyloid burden. That sleep disturbance would be a candidate risk factor for Al...
Source: The Lancet Neurology - Category: Neurology Source Type: research
ConclusionThis study implemented a systematic, bibliometric approach to quantitively assess the breadth of the TMS literature base and identify temporal publication and authorship trends. Drawing on these insights may aid understanding of historical progress in TMS over the last 30 years and help identify into unmet needs and opportunities to improve scientific and publishing practices to contribute to the future health of the field. These findings are likely to be relevant to researchers, clinicians, funders, industry collaborators and other stakeholders.
Source: Brain Stimulation - Category: Neurology Source Type: research
Condition:   Alzheimer Disease Intervention:   Diagnostic Test: [F-18]AV-1451-PET Sponsor:   University of Alabama at Birmingham Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Parkinson's Disease Interventions:   Dietary Supplement: Niacin;   Dietary Supplement: Niacinamide;   Other: Placebo Sponsor:   VA Office of Research and Development Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Traynor BJ, Chia R, Chung SJ, International Parkinson's Disease Genomics Consortium (IPDGC), COURAGE-PD Consortium, Hardy JA, Brice A, Wood NW, Houlden H, Shulman JM, Morris HR, Gasser T, Krüger R, Heutink P, Sharma M, Simón-Sánchez J, Nalls MA, Singleton AB, Scholz SW Abstract Genetics has proven to be a powerful approach in neurodegenerative diseases research, resulting in the identification of numerous causal and risk variants. Previously, we introduced the NeuroX Illumina genotyping array, a fast and efficient genotyping platform designed for the investigation of genetic variation in neurode...
Source: Neurobiology of Aging - Category: Geriatrics Authors: Tags: Neurobiol Aging Source Type: research
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