Aberrant accumulation of ErbB4 in progressive supranuclear palsy
ConclusionsOur present results suggest that NRG1/ErbB4 signalling could be an important event in the pathogenesis of PSPThis article is protected by copyright. All rights reserved.
Conclusion: The Activa PC IPG demonstrates a significantly reduced battery life of 2.1 years, with a median battery life of 4.5 years in comparison to 6.6 years in the Kinetra IPG. Future technology developments should therefore be focused on improving the battery life of the newer IPG systems.Stereotact Funct Neurosurg
Alzheimer's patients older than 65 benefit the most benefit from deep brain stimulation, according to findings from a recent phase II clinical trial.
“As it prepares to turn 70, the NHS is coming towards the worst decade in its existence as far as funding goes,” began the discussion of health and social care. The mover of the motion said that, “services have been repeatedly run down by a government that prefers tax cuts for the wealthy to a well-funded NHS… we now have a permanent winter for our NHS and workloads and stress loads have gone through the roof for many members.” Tracy Holmes, from Sefton local government branch, told delegates about the bad practise in homecare she had witnessed: from visits of just five minutes scheduled...
Condition: Parkinson Disease Interventions: Biological: VY-AADC02; Other: Placebo Sponsor: Voyager Therapeutics Not yet recruiting
Conditions: Alzheimer Disease; Mild Cognitive Impairment Intervention: Diagnostic Test: Pramlintide challenge test Sponsor: Boston University Not yet recruiting
Xueping Chen, Qian-Qian Wei, Yongping Chen, Bei Cao, RuWei Ou, Yanbing Hou, Xiaoqin Yuan, Lingyu Zhang, Hui Liu, Huifang Shang
Nicolas Gigu ère, Samuel Burke Nanni, Louis-Eric Trudeau
Authors: Müller T, Möhr JD Abstract INTRODUCTION: Parkinson's disease is a chronic, neurodegenerative disease. Its symptoms and course are heterogeneous. After several years of investigative drug studies, levodopa remains the most efficacious drug despite its long-term limitations. Consequently, research into new drug delivery modes is ongoing. Areas covered: This review summarizes past and current advances of levodopa therapy with a focus on long-term patient management. Current research aims to increase drug bioavailability and to deliver it to the brain continuously. Reduced fluctuations improve drug e...
Notice NOT-AG-18-019 from the NIH Guide for Grants and Contracts
Traynor BJ, Chia R, Chung SJ, International Parkinson's Disease Genomics Consortium (IPDGC), COURAGE-PD Consortium, Hardy JA, Brice A, Wood NW, Houlden H, Shulman JM, Morris HR, Gasser T, Krüger R, Heutink P, Sharma M, Simón-Sánchez J, Nalls MA, Singleton AB, Scholz SW Abstract Genetics has proven to be a powerful approach in neurodegenerative diseases research, resulting in the identification of numerous causal and risk variants. Previously, we introduced the NeuroX Illumina genotyping array, a fast and efficient genotyping platform designed for the investigation of genetic variation in neurode...