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NLRP3 Inflammasome Activation in a Transgenic Amyotrophic Lateral Sclerosis Model

In conclusion, our results showed the activation of the NLRP3 inflammasome in the brain of SOD1G93A rats, indicating that inflammation plays a main role in ALS.
Source: Inflammation - Category: Allergy & Immunology Source Type: research

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TheNational Institute on Drug Abuse (NIDA) is seeking interested parties to license or co-develop GDNFOS peptides and non-coding RNAs as therapeutic agents for neurodegenerative diseases.Glial cell line-derived neurotrophic factor (GDNF) is a small human protein encoded by the GDNF gene. GDNF has been effective therapy in laboratory animal models of Parkinson's disease and protects several types of neurons in the brain and peripheral nervous system. Researchers at the NIDA have discovered primate-specific GDNFOS, encoded by the opposite strand of glial cell derived neurotrophic factor (GDNF) gene. The GDNFOS gene encodes f...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research
SAN BRUNO, Calif. and LOS ANGELES, April 26, 2018 -- (Healthcare Sales &Marketing Network) -- Neuraltus Pharmaceuticals, Inc., a privately-held pharmaceutical company dedicated to developing innovative therapeutics for neurodegenerative diseases, today a... Biopharmaceuticals, Neurology Neuraltus Pharmaceuticals, Amyotrophic Lateral Sclerosis
Source: HSMN NewsFeed - Category: Pharmaceuticals Source Type: news
In the diagnosis and assessment of amyotrophic lateral sclerosis (ALS), the roles of nerve and muscle ultrasound vary widely. Nerve ultrasound has revealed that cross-sectional area (CSA) was decreased in the median and ulnar nerves and the nerve roots in ALS. In addition, a longitudinal study demonstrated the possibility that ulnar nerve CSA could be a useful biomarker to monitor disease progression in ALS. Muscle ultrasound is useful for detecting widespread fasciculations in the diagnosis of ALS.
Source: Clinical Neurophysiology - Category: Neuroscience Authors: Source Type: research
The diagnosis of amyotrophic lateral sclerosis (ALS) requires (1) evidence for extensive upper and lower motor neuron dysfunction, (2) progressive course, and (3) exclusion of other causes of motor neuronal loss. So far, a number of diagnostic criteria for ALS have been proposed, such as El Escorial (1990), revised El Escorial (1998), Awaji (2008), and updated Awaji (2015). According to the frequent revision/proposal criteria, electrodiagnostic criteria for ALS are somewhat confusing. In these criteria, the body motor system are divided into 4 regions; cranial, cervical, thoracic, and lumbosacral, and evidence for upper an...
Source: Clinical Neurophysiology - Category: Neuroscience Authors: Source Type: research
In amyotrophic lateral sclerosis (ALS), the usefulness of ultrasonography has been increasingly recognized as a powerful tool to detect fasciculations. However, the distribution of fasciculations in the whole body has not been fully elucidated. The aim of this study was to disclose it by muscle ultrasonography.In 85 consecutive ALS patients (40 men; the mean age, 66.8  years; the mean disease duration, 16.7 months), ultrasonography was performed in the 11 muscles (the tongue and both sides of the biceps brachii, first dorsal interosseous [FDI], Th10 paraspinalis, vastus lateralis and tibialis anterior).
Source: Clinical Neurophysiology - Category: Neuroscience Authors: Source Type: research
Peripheral sensory nerve involvement is inconspicuous in patients with amyotrophic lateral sclerosis (ALS), while previous reports on the frequency and extent of sensory nerve involvement in ALS are not consistent. We investigated the differences in the peripheral sensory nerve conduction between 160 patients with ALS and 69 control participants. Motor and antidromic sensory nerve conduction studies were conducted for the median, ulnar and sural nerves. In ALS patients, sensory conduction velocity (SCV) was significantly lower in all examined nerves than that in controls.
Source: Clinical Neurophysiology - Category: Neuroscience Authors: Source Type: research
We examined whether muscle ultrasonography is an effective diagnostic tool of amyotrophic lateral sclerosis (ALS). Analysis was performed in 17 patients with ALS or motor neuron disease. An Aplio XG ultrasonography device and a 7.5-MHz linear probe were used to observe 11 muscles for 20  s to determine the presence or absence of fasciculation. The overall fasciculation positive rate was 68.5%, and it was higher in the limbs.
Source: Clinical Neurophysiology - Category: Neuroscience Authors: Source Type: research
AbstractNeurogranin (Ng) is a post-synaptic protein that previously has been shown to be a biomarker for synaptic function when measured in cerebrospinal fluid (CSF). The CSF concentration of Ng is increased in Alzheimer ’s disease dementia (ADD), and even in the pre-dementia stage. In this prospective study, we used an enzyme-linked immunosorbent assay that quantifies Ng in CSF to test the performance of Ng as a marker of synaptic function. In 915 patients, CSF Ng was evaluated across several different neurodege nerative diseases. Of these 915 patients, 116 had a neuropathologically confirmed definitive diagnos...
Source: Acta Neuropathologica - Category: Neurology Source Type: research
The astrophysicist Stephen Hawking, arguably the most famous patient with amyotrophic lateral sclerosis (ALS) to date, died on March 14, 2018. He was exceptional in many respects, and so was his disease. Hawking's long survival after an ALS diagnosis (over 50 years) gave hope to other patients, and his case helped ALS specialists illustrate disease variability and prognostic uncertainty. When caring for people with a neurodegenerative disease that usually progresses rapidly, like ALS, prognosis is key to plan medical care and future needs.
Source: Lancet Neurology - Category: Neurology Authors: Tags: Editorial Source Type: research
Conditions:   Amyotrophic Lateral Sclerosis;   Motor Neuron Disease Intervention:   Biological: IC14 Sponsor:   Implicit Bioscience Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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