Evaluation of protein levels of autophagy markers (Beclin 1 and SQSTM1/p62) and phosphorylation of cyclin E in the placenta of women with preeclampsia.

Evaluation of protein levels of autophagy markers (Beclin 1 and SQSTM1/p62) and phosphorylation of cyclin E in the placenta of women with preeclampsia. Cell Mol Biol (Noisy-le-grand). 2017 Dec 30;63(12):51-55 Authors: Akcora Yildiz D, Irtegun Kandemir S, Agacayak E, Deveci E Abstract Preeclampsia is a severe multisystem disorder, and its pathophysiology is still not completely understood. Autophagy, a recycling process that maintains cellular homoeostasis during differentiation and development, is controversial regarding increased or decreased autophagic activity in preeclampsia. The aim of this study was to determine whether autophagy is increased in the placentas of women with preeclampsia by examining the protein levels of autophagy markers (Beclin 1 and SQSTM1/p62) and phosphorylation of cyclin E. For this purpose, placentas from preeclampsia (n=10) and control (n=10) pregnancies were included in this study. The protein expression of autophagy-related markers Beclin1, SQSTM1/p62 and phosphorylation status of cyclin E were detected by Western blot. Our data showed that the protein levels of both Beclin 1 and SQSTM1/p62 were significantly increased, while the phosphorylation level of cyclin E was significantly decreased in placentas with preeclampsia compared to those derived from controls. The results of this study suggest that the autophagic activity is perpetually increased in preeclampsia and cyclin E protein stabilisation might be involved in the i...
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research

Related Links:

[Evolution of the number of incident cases, stage and first treatments for prostate cancer in France between 2001 and 2016]. Prog Urol. 2019 Jan 08;: Authors: Delporte G, Olivier J, Ruffion A, Crouzet S, Cavillon C, Helfrich O, Leroy X, Villers A Abstract INTRODUCTION: No studies of French hospital registries for prostate cancer (PCa) have been published since the 2012 USPSTF recommendations. MATERIAL: This is a multicenter cohort study based on hospital data of prostate biopsies (PB) in 3 health centers between 2001 and 2016. The main objective is to describe the evolution of i...
Source: Progres en Urologie - Category: Urology & Nephrology Tags: Prog Urol Source Type: research
No human cases have been identified, but health officials warn the disease can be passed to people from infected animals
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news
Data from two phase 3 trials show the efficacy of single-dose tafenoquine in preventing malarial relapse but underscore the need for appropriate patient selection.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Infectious Diseases News Source Type: news
This report titled Double Jeopardy: The Older Negro in America Today presented data that documented the hardships faced by African Americans as they aged in a society that marginalized them. Using critical race theory (CRT), this article reviews the report and addresses the contemporary state of African Americans. It specifically focuses on income, education, poverty, and health status. The article also includes the scholarship of seminal scholars on the Black aged as context. It ends with policy implications that address changes that will continue to improve quality of life for older African Americans. PMID: 30636560 ...
Source: Social Work in Public Health - Category: International Medicine & Public Health Tags: Soc Work Public Health Source Type: research
At least three wrongful death lawsuits have now been filed against Dr. William Husel, the Columbus-area Mount Carmel Health System, and nurses and pharmacists employed by the system
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
CONCLUSIONS: The patient's perception of safety is good, although it can be improved. No strengths have been identified. The weaknesses identified are staffing, management support for patient safety, handoffs and transitions, and safety perception. PMID: 30642698 [PubMed - as supplied by publisher]
Source: Gaceta Sanitaria - Category: International Medicine & Public Health Tags: Gac Sanit Source Type: research
Authors: Kalani M, Choopanizadeh M, Rasouli M Abstract Visceral leishmaniasis (VL) is a life threatening disease in which a variety of cytokines regulating the immune responses can determine its outcome. As based on their region in the gene, some single nucleotide polymorphisms (SNP) can influence the expression of their corresponding proteins, this study aimed to investigate the association between SNP in the IL-10, IL-12, IFN-γ genes and susceptibility to VL. The study was carried out on 120 patients with VL, 67 patients' families (family group), and 102 healthy individuals with positive leishmanin skin tes...
Source: Pathogens and Global Health - Category: International Medicine & Public Health Tags: Pathog Glob Health Source Type: research
An attorney says an additional wrongful death lawsuit has been filed alleging an Ohio doctor and the hospital where he worked caused a patient's death by improperly prescribing a lethal dose of pain medication
Source: ABC News: Health - Category: Consumer Health News Tags: Health Source Type: news
Authors: Lang TA PMID: 30644797 [PubMed - as supplied by publisher]
Source: Public Health Reports - Category: International Medicine & Public Health Tags: Public Health Rep Source Type: research
Authors: Tobin-Tyler E, Teitelbaum JB PMID: 30644791 [PubMed - as supplied by publisher]
Source: Public Health Reports - Category: International Medicine & Public Health Tags: Public Health Rep Source Type: research
More News: Biology | Molecular Biology | Study | Women