Jim Lynskey has been fitted with a battery-operated heart
Jim Lynskey, from Redditch, Worcestershire, has an enlarged heart, known as dilated cardiomyopathy, after he and his twin sister, Grace, caught viral meningitis at just two weeks old.
Authors: Sirico G, Montisci A, Secchi F, Mantica M Abstract A significant number of sudden death (SD) is observed in myotonic dystrophy (DM1) despite pacemaker implantation and some consider the ICD to be the preferential device in patients with conduction disease. According to the latest guidelines, prophylactic ICD implantation in patients with neuromuscular disorder should follow the same recommendations of non-ischemic dilated cardiomyopathy, being reasonable when pacing is needed. We here report a case of DM1 patient who underwent ICD implantation even in the absence of conduction disturbances on ECG and ventr...
Publication date: Available online 2 July 2020Source: Stem Cell ResearchAuthor(s): Sabine Rebs, Farbod Sedaghat-Hamedani, Elham Kayvanpour, Benjamin Meder, Katrin Streckfuss-Bömeke
Conclusions: Caring for patients with ATTRwt places a significant economic burden on the healthcare system. The study emphasizes the cost saving potential for medical interventions in this patient population. PMID: 32609021 [PubMed - as supplied by publisher]
Conclusion: Overall, these results suggest that CMC cardiomyogenic lineage commitment biases cardiac repair and, further, that enhanced anti-fibrogenic paracrine signaling potency may underlie, in part, their improved therapeutic utility.
Conclusion: Myocardial injury in obese and non-obese T2DM may represent two different types of complications. Obese T2DM individuals, compared to non-obese individuals, are more prone to develop cardiac systolic dysfunction due to severe and persistent myocardial lipotoxicity. Additionally, anti-oxidative dysfunction may be a key factor leading to myocardial injury in non-obese T2DM.
Publication date: Available online 1 July 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Xiao Yang, Chenyang Zhang, Jun Zhang, Guisheng Chen, Li Zhao, Ping Yang, Huilu Li, Youming Long
Publication date: Available online 1 July 2020Source: IDCasesAuthor(s): Colomba Claudia, Rubino Raffaella, Anastasia Antonio, Palermo Gabriele, Lo Porto Davide, Abbott Michelle, Bonura Silvia, Cascio Antonio
This study demonstrates that formalin treatment increases the stability and immunogenicity of CVB1-VLP vaccine and may offer a universal tool for the stabilization of VLPs in the production of more efficient vaccines.
This study demonstrates that formalin treatment increases the stability and immunogenicity of CVB1-VLP vaccine and may offer a universal tool for the stabilization of VLPs in the production of more efficient vaccines. PMID: 31491431 [PubMed - as supplied by publisher]
Enterovirus1 (EV) infections are common in all age groups. They are usually asymptomatic or cause only mild respiratory symptoms, but can also lead to more severe illness including hand, foot and mouth disease, myocarditis, meningitis, encephalitis, pancreatitis, systemic infection in newborns and paralysis. EV infections may also play a role in the pathogenesis of chronic diseases such as dilated cardiomyopathy , chronic fatigue syndrome  and type 1 diabetes2 (T1D) [3–5].