Jim Lynskey has been fitted with a battery-operated heart

Jim Lynskey, from Redditch, Worcestershire, has an enlarged heart, known as dilated cardiomyopathy, after he and his twin sister, Grace, caught viral meningitis at just two weeks old.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Condition:   Transthyretin Amyloidosis (ATTR) With Cardiomyopathy Interventions:   Drug: Placebo;   Drug: Patisiran Sponsor:   Alnylam Pharmaceuticals Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Infections, especially pneumococcal septicemia, meningitis, andSalmonella osteomyelitis, are a major cause of morbidity and mortality in patients with sickle cell disease (SCD). SCD increased susceptibility to infection, while infection leads to SCD-specific pathophysiological changes. The risk of infectious complications is highest in children with a palpable spleen before 6 months of age. Functional splenectomy, the results of repeated splenic infarctions, appears to be an important host-defense defect. Infection is the leading cause of death, particularly in less developed countries. Defective host-defense mechanisms en...
Source: Mediterranean Journal of Hematology and Infectious Diseases - Category: Hematology Source Type: research
Publication date: Available online 24 June 2019Source: Canadian Journal of CardiologyAuthor(s): Martin S. Maron, Ethan J. Rowin, Barry J. Maron
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
AbstractPurpose of reviewThis review summarizes the clinical characteristics and updated outcomes of primary pediatric cardiomyopathies including dilated (DCM), hypertrophic (HCM), and restrictive cardiomyopathy (RCM), and briefly discusses left ventricular non-compaction (LVNC) and arrhythmogenic cardiomyopathy (ACM), primarily arrythmogenic right ventricular cardiomyopathy (ARVC).Recent findingsPediatric cardiomyopathies are diseases of the heart muscle with an estimated annual incidence of 1.1 –1.5 cases per 100,000. They are progressive in nature and are frequently caused by a genetic mutation causing a structura...
Source: Current Treatment Options in Cardiovascular Medicine - Category: Cardiology Source Type: research
We present the case of an infant with end-stage dilated cardiomyopathy and intractable heart failure who received pulmonary artery banding. Serial follow-up through two-dimensional and three-dimensional echocardiography revealed gradual improvement in the left ventricular ejection fraction and favorable remodeling. The result of three-dimensional speckle tracking suggested that this benefit is associated with improvements in global strain and intraventricular dyssynchrony.
Source: Pediatric Cardiology - Category: Cardiology Source Type: research
MyoKardia’s said data on its wrist-worn digital health device was published in an article titled, “Machine Learning Detection of Obstructive Hypertrophic Cardiomyopathy (oHCM) Using a Wearable Biosensor,” in the Nature Partner Journal, Digital Medicine. The South San Francisco-based company said results from an exploratory study provided encouraging evidence of the potential for a wrist-worn biosensor to screen for obstructive hypertrophic cardiomyopathy. The study demonstrated that continuous monitoring using a wrist-worn photoplethysmography (PPG) digital health devic...
Source: MDDI - Category: Medical Devices Authors: Tags: Business Cardiovascular Source Type: news
A father accused in his son's meningitis death testified Monday in a southern Alberta courtroom where the man and his wife are accused of failing to get medical attention for their toddler.
Source: CBC | Health - Category: Consumer Health News Tags: News/Canada/Calgary Source Type: news
Recent advances in DNA sequencing have expanded our understanding of the molecular basis of genetic disorders and increased the utilization of clinical genomic tests. Given the paucity of evidence to accurately classify each variant and the difficulty of experimentally evaluating its clinical significance, a large number of variants generated by clinical tests are reported as variants of unknown clinical significance. Population-scale variant databases can improve clinical interpretation. Specifically, pathogenicity prediction for novel missense variants can use features describing regional variant constraint. Constrained ...
Source: Genome Research - Category: Genetics & Stem Cells Authors: Tags: METHOD Source Type: research
ConclusionIn a real-world setting, no benefit was evident for patients with non-ischemic cardiomyopathy and reduced left ventricular ejection fraction by adding ICD therapy in a short-term follow-up of 12  months in contrast to patients with ischemic cardiomyopathy.Graphic abstract
Source: Clinical Research in Cardiology - Category: Cardiology Source Type: research
Enterovirus1 (EV) infections are common in all age groups. They are usually asymptomatic or cause only mild respiratory symptoms, but can also lead to more severe illness including hand, foot and mouth disease, myocarditis, meningitis, encephalitis, pancreatitis, systemic infection in newborns and paralysis. EV infections may also play a role in the pathogenesis of chronic diseases such as dilated cardiomyopathy [1], chronic fatigue syndrome [2] and type 1 diabetes2 (T1D) [3–5].
Source: Journal of Clinical Virology - Category: Virology Authors: Source Type: research
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