Effects of ketamine on vocal impairment, gait changes, and anhedonia induced by bilateral 6-OHDA infusion into the substantia nigra pars compacta in rats: therapeutic implications for Parkinson's disease.

In conclusion, the substantia nigra lesion with 6-hydroxydopamine induced subtle motor and non-motor manifestations, reflecting key features of the wide clinical spectrum of early Parkinson's disease. Furthermore, the present results suggest a potential efficacy of ketamine on depression and gait alterations in Parkinson's disease. PMID: 29307665 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29307665?dopt=Abstract

Source: Behavioural Brain Research - January 4, 2018 Category: Neurology Authors: Vecchia DD, Kanazawa LKS, Wendler E, de Almeida Soares Hocayen P, Bruginski E, Campos FR, Stern CAJ, Vital MABF, Miyoshi E, Wöhr M, Schwarting RKW, Andreatini R Tags: Behav Brain Res Source Type: research