Clinical impact of delayed catheter removal for patients with central venous catheter-related gram-negative bacteremia

Conclusion CVCs should be removed early to improve clinical outcomes in patients with gram-negative CRBSI, especially where there is high prevalence of MDR isolates.
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research

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The objective of our study was to determine the spectrum of bacterial colonization individually among intensive care unit patients. A retrospective observational study was performed in the Intensive Care Unit of Emergency Clinical County Hospital of Oradea during 2017. Medical records of the patients were used for evaluation of source of ICU admission, previous antibiotic therapy, comorbidities, and length of hospital stay. Nasal and groin swabs for MRSA detection and rectal swabs for ESBL, VRE, and CRE detection were collected upon ICU admission of all patients in the first 24 hours and after 7 days. Swab samples were pro...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
ConclusionsThis study did not identify a relationship between the resistance profile of Pseudomonas aeruginosa and mortality.
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
ConclusionsColistin remains an important option for severe MDR-GNB infections when other treatments are not available. Despite inherent difficulties in optimizing its use due to peculiar PK/PD characteristics, colistin was mostly used appropriately in a country endemic for MDR-GNB.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
ConclusionGiven the concern for MDR P. aeruginosa infections in CF patients, BT may offer a viable anti-infective adjunct to traditional antibiotic therapy.
Source: Infection - Category: Infectious Diseases Source Type: research
ConclusionsThis study did not identify a relationship between the resistance profile of Pseudomonas aeruginosa and mortality.
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
Authors: Lee TW, Bae E, Kim JH, Jang HN, Cho HS, Chang SH, Park DJ Abstract The use of colistin in the treatment of multidrug-resistant Gram-negative bacterial infections is restricted due to nephrotoxicity. We investigated the effects of aged black garlic extract (ABGE) on colistin-induced kidney injury in rats. Rats were assigned to four groups. Normal saline was intraperitoneally and intragastrically injected for control group. ABGE was intragastrically injected for garlic group. Ten mg/kg of colistin was intraperitoneally injected for 6 consecutive days for colistin group. One percent of ABGE was done 30&thinsp...
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
CONCLUSIONS: AKI in patients with carbapenem-resistant Enterobacteriaceae treated with polymyxin increases both length of stay in hospital and total costs. PMID: 30466325 [PubMed - as supplied by publisher]
Source: Journal of Medical Economics - Category: Health Management Tags: J Med Econ Source Type: research
Introduction: Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) are lethal nosocomial infections. Identifying patients at risk for drug-resistant pathogens (DRPs) is important to achieve appropriate antibiotic therapy and to reduce overuse of broad-spectrum antibiotics. The aim of this study is to clarify the risk factors for DRPs in patients with HAP and VAP at diagnosis.Methods: This prospective observational study was conducted in adult patients with HAP and VAP at Nagoya University Hospital from March, 2010 through October, 2016. P. aeruginosa, methicillin-resistant S. aureus, extended-spectru...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory Infections Source Type: research
In this study, [(3)H]MTX uptake was observed by using human OAT1 and OAT3-overexpressing HEK293 cells in the presence or absence of NSAIDs-Glu. All examined NSAIDs-Glu exhibited concentration-dependent inhibitory effects on MTX uptake via OAT1 and OAT3. Our results indicated that NSAIDs-Glu are more potent (5- to 15-fold) inhibitors of OAT3 than OAT1. Moreover, stereoselective inhibitory effects of NSAIDs-Glu on OATs-mediated MTX uptake were not observed, unlike on MRPs-mediated transport. These findings suggest that inhibition of OAT1 and OAT3-mediated renal uptake of MTX by plasma NSAIDs-Glu may be one of the competitive...
Source: Biological and Pharmaceutical Bulletin - Category: Drugs & Pharmacology Authors: Tags: Biol Pharm Bull Source Type: research
ConclusionsHigh quality intensive assistance for sepsis episodes needs a clear plan of cure, aimed to complete infection source control, in a complex multidisciplinary interplay of specialists and intensive care physicians.
Source: Journal of Medical Case Reports - Category: Journals (General) Source Type: research
More News: Central Venous Catheterization | Infectious Diseases | Multidrug Resistance | Renal Failure