Microarray ‐based comparative genomic hybridisation reveals additional recurrent aberrations in adult patients evaluated for myelodysplastic syndrome with normal karyotype

Source: British Journal of Haematology - Category: Hematology Authors: Tags: Correspondence Source Type: research

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Conditions:   Acute Myeloid Leukemia;   Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome;   Chronic Myelogenous Leukemia, BCR-ABL1 Positive;   Chronic Myelomonocytic Leukemia;   Myelodysplastic Syndrome;   Myelodysplastic/Myeloproliferative Neoplasm;   Secondary Acute My eloid Leukemia Interventions:   Drug: Edetate Calcium Disodium;   Dietary Supplement: Multivitamin;   Drug: Succimer Sponsors:   M.D. Anderson Cancer Center;   Nationa...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Eunice Wang, MD, of Roswell Park Comprehensive Cancer Center, Buffalo, NY, discusses extending the use of hypomethylating agents from patients with high risk myelodysplastic syndromes (MDS) to individ... Author: VJHemOnc Added: 08/15/2018
Source: Oncology Tube - Category: Cancer & Oncology Source Type: podcasts
There has been an influx of novel therapies within the field of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Here, Eunice Wang, MD, of Roswell Park Comprehensive Cancer Center, Bu... Author: VJHemOnc Added: 08/15/2018
Source: Oncology Tube - Category: Cancer & Oncology Source Type: podcasts
Myelodysplastic syndromes (MDS) are a heterogeneous group of malignant stem cell disorders characterised by ineffective, dysplastic, clonal haematopoiesis. The acquisition of mutations in a haematopoietic cell, due to aging or secondary genetic insults, drives clonal expansion and confers an increased risk of neoplasia [1,2]. In the pre-malignant state, this phenomenon is known as clonal haematopoiesis of indeterminate potential (CHIP)2. Subsequent expansion of the founding clone and sequential acquisition of additional driver mutations, typically promoting self-renewal and a proliferative advantage, together with a dysfun...
Source: Leukemia Research - Category: Hematology Authors: Tags: Meeting report Source Type: research
Publication date: Available online 13 August 2018Source: The Lancet HaematologyAuthor(s): Tapan M Kadia, Jorge Cortes, Farhad Ravandi, Elias Jabbour, Marina Konopleva, Christopher B Benton, Jan Burger, Koji Sasaki, Gautam Borthakur, Courtney D DiNardo, Naveen Pemmaraju, Naval Daver, Alessandra Ferrajoli, Xuemei Wang, Keyur Patel, Jeffrey L Jorgensen, Sa Wang, Susan O'Brien, Sherry Pierce, Carla TuttleSummaryBackgroundFront-line therapy for elderly or unfit patients with acute myeloid leukaemia (AML) remains unsatisfactory with poor outcomes and excessive toxicity. We studied a new low-intensity regimen of cladribine combin...
Source: The Lancet Haematology - Category: Hematology Source Type: research
Publication date: 13 August 2018Source: Cancer Cell, Volume 34, Issue 2Author(s): Stanley Chun-Wei Lee, Khrystyna North, Eunhee Kim, Eunjung Jang, Esther Obeng, Sydney X. Lu, Bo Liu, Daichi Inoue, Akihide Yoshimi, Michelle Ki, Mirae Yeo, Xiao Jing Zhang, Min Kyung Kim, Hana Cho, Young Rock Chung, Justin Taylor, Benjamin H. Durham, Young Joon Kim, Alessandro Pastore, Sebastien MonetteSummaryMutations affecting RNA splicing factors are the most common genetic alterations in myelodysplastic syndrome (MDS) patients and occur in a mutually exclusive manner. The basis for the mutual exclusivity of these mutations and how they co...
Source: Cancer Cell - Category: Cancer & Oncology Source Type: research
Source: Annals of Hematology - Category: Hematology Source Type: research
The prognostic significance of global aberrant alternative splicing in patients with myelodysplastic syndrome, Published online: 13 August 2018; doi:10.1038/s41408-018-0115-2The prognostic significance of global aberrant alternative splicing in patients with myelodysplastic syndrome
Source: Blood Cancer Journal - Category: Hematology Authors: Source Type: research
This article is protected by copyright. All rights reserved. PMID: 30101490 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
Authors: Tanaka H, Kuwabara C, Kayamori K, Shimizu R, Suzuki Y PMID: 30089748 [PubMed - as supplied by publisher]
Source: Journal of Clinical and Experimental Hematopathology : JCEH - Category: Hematology Tags: J Clin Exp Hematop Source Type: research
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