Lymphoma following clozapine exposure: More information needed

Clozapine is the drug of choice for treatment resistant schizophrenia and has demonstrated superiority to other antipsychotics; however, its adverse event profile precludes use as a first line agent.(Meltzer, 2012) The carcinogenicity of clozapine remains unknown due to conflicting data. A systematic review concluded that antipsychotics as a class cannot be considered carcinogenic in humans, despite rodent data suggesting the contrary.(Fond et al., 2012) Notably, authors highlight that clozapine, specifically, may be associated with an increased risk of leukemia.
Source: Schizophrenia Research - Category: Psychiatry Authors: Tags: Letter to the Editor Source Type: research