CD8+ T cells and IFN- γ induce autoimmune myelofibrosis in mice.

In conclusion, our results demonstrate that CD8+ T cells and IFN-γ are associated with autoimmune myelofibrosis, a finding that may allow targeting of CD8+ T cells and IFN-γ as a therapeutic targets. PMID: 29307587 [PubMed - as supplied by publisher]
Source: Journal of Autoimmunity - Category: Allergy & Immunology Authors: Tags: J Autoimmun Source Type: research

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Authors: Senjo H, Higuchi T, Morimoto M, Koyamada R, Yanaoka C, Okada S Abstract An 81-year-old Japanese man presented with constitutional symptoms and anemia and was diagnosed with giant cell arteritis (GCA) and myelodysplastic syndrome (MDS) simultaneously. His symptoms and anemia improved promptly with steroids; however, the MDS rapidly progressed to overt leukemia. While MDS patients are at an increased risk of autoimmune diseases, an association with GCA has rarely been reported. This case illustrates the importance of considering GCA as a cause of anemia in elderly patients if MDS is already diagnosed, even i...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Conclusion: DAH is a severe disorder, with nonspecific presentation, caused by a wide spectrum of disease, as demonstrated by this series. Diagnosis requires high clinical suspicion and a thorough work-up.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Diffuse Parenchymal Lung Disease Source Type: research
Conclusion This nationwide study demonstrates the efficacy of steroids for SIAD-associated MDSs but a high frequency of steroid dependence. The response to biologics seems low, but rituximab and azacytidine seem promising.
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
CONCLUSION: MDS patients with anti-erythroblast autoimmunity showed increased BM apoptosis, suggesting that the autoimmune reaction may contribute to an unfavorable BM microenvironment for optimal erythropoiesis. PMID: 27232106 [PubMed - as supplied by publisher]
Source: Transfusion - Category: Hematology Authors: Tags: Transfusion Source Type: research
ConclusionsVDR polymorphisms may contribute to susceptibility to AA and influence the severity and prognosis of AA in a Chinese population.
Source: Clinical and Laboratory Haematology - Category: Hematology Authors: Tags: Original Article Source Type: research
In this study, 123 patients with MDS and SIADs were analysed. Results. Mean age was 70 years (s.d. 13) and the male:female ratio was 2. The SIADs were systemic vasculitis in 39 (32%) cases, CTD in 31 (25%) cases, inflammatory arthritis in 28 (23%) cases, a neutrophilic disorder in 12 (10%) cases and unclassified in 13 cases (11%). The SIADs fulfilled the usual classification criteria in 75 (66%) cases, while complete criteria were not reached in 21 (19%) cases. A significant association was shown between chronic myelomonocytic leukaemia (CMML) and systemic vasculitis (P = 0.0024). One hundred and eighteen (96%) SIAD patien...
Source: Rheumatology - Category: Rheumatology Authors: Tags: Systemic Lupus Erythematosus and Autoimmunity CLINICAL SCIENCE Source Type: research
Authors: Liu C, Grossman BJ Abstract Randomized clinical trials (RCTs) have determined, in surgical and critically ill patients, relatively safe hemoglobin (Hb) thresholds of 7-8 g/dL to guide restrictive transfusion of red blood cells (RBCs). However, in patients with various hematologic disorders, strong evidence in support of such an approach is sparse and the optimal transfusion practice is yet to be defined. This review focuses on RBC transfusion practice in three hematologic diseases and a treatment strategy, including autoimmune hemolytic anemia, thalassemia, myelodysplastic syndrome, and hematopoietic stem ...
Source: Hematology ASH Education Program - Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research
In conclusion, our data show that clonal hematopoiesis emerges in the majority of patients with AA, including children and young adults, can be detected early in disease, and has a mutational spectrum largely distinct from MDS. Our results highlight that in the absence of morphologic features of myelodysplasia, the presence of clonal hematopoiesis with somatic mutations cannot be used to distinguish MDS from AA. Future longitudinal studies of clonal hematopoiesis in AA will help to explain differences in patients’ disease course, and will enable personalized treatment approaches in AA.Citation Format: Daria V. Babush...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Molecular and Cellular Biology Source Type: research
Haemolytic transfusion reactions (HTRs) may be immediate/acute (AHTR) usually due to immune ABO incompatibility or delayed (DHTR) seen days to weeks following transfusion and caused by an anamnestic immune response to red cell antigens (Kidd, Rh, Duffy and others). AHTR may cause severe morbidity and mortality even if recognized early. Presently, there is no therapy that can reliably treat the effects of acute haemolysis. Therefore, RBC (and other blood components) should be transfused only if clinically indicated. Strict adherence to guidelines and SOP's is essential for prevention of this avoidable severe complication. A...
Source: ISBT Science Series - Category: Hematology Authors: Tags: Invited Review Source Type: research
Publication date: Available online 2 February 2015 Source:Cancer Genetics Author(s): Daria V. Babushok , Nieves Perdigones , Juan C. Perin , Timothy S. Olson , Wenda Ye , Jacquelyn J. Roth , Curt Lind , Carine Cattier , Yimei Li , Helge Hartung , Michele E. Paessler , Dale M. Frank , Hongbo M. Xie , Shanna Cross , Joshua D. Cockroft , Gregory M. Podsakoff , Dimitrios Monos , Jaclyn A. Biegel , Philip J. Mason , Monica Bessler Acquired aplastic anemia (aAA) is a nonmalignant disease caused by autoimmune destruction of early hematopoietic cells. Clonal hematopoiesis is a late complication, seen in 20–25% of older pat...
Source: Cancer Genetics - Category: Cancer & Oncology Source Type: research
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