Metastatic diseases of the central nervous system - neuropathologic aspects.

Metastatic diseases of the central nervous system - neuropathologic aspects. Handb Clin Neurol. 2018;149:67-73 Authors: Lopes MBS Abstract A large percentage of patients with cancer will develop brain metastases, and many of them will die within a few months following diagnosis of intracranial metastasis. Although the majority of the central nervous system metastases are derived from a well-known primary neoplasm, about 5-10% of brain metastases are from an unknown source, making the tissue diagnosis a first step in the search for a primary malignancy. The pathologist utilizes several immunohistochemical and molecular diagnostic tools for such investigation, helping the clinical oncologist to narrow down the clinical and radiologic exploration. Recently, analysis of actionable biomarkers for target therapy in brain metastasis has become significant due to reports of discrepancy of potential biomarkers between primary tumors and metastatic brain deposits. PMID: 29307362 [PubMed - in process]
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: Handb Clin Neurol Source Type: research

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Conditions:   Metastatic Breast Cancer;   Brain Metastases Interventions:   Drug: Nivolumab;   Radiation: Stereotactic Radiosurgery Sponsors:   H. Lee Moffitt Cancer Center and Research Institute;   Bristol-Myers Squibb Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Induction of Apoptosis in Metastatic Breast Cancer Cells: XV. Downregulation of DNA Polymerase-α - Helicase Complex (Replisomes) and Glyco-Genes. Adv Exp Med Biol. 2018;1112:199-221 Authors: Basu SC, Boyle P, Ma R, Agarwal A, Basu M, Moskal JR, Banerjee S, Tuteja N Abstract In normal and cancer cells, successful cell division requires accurate duplication of chromosomal DNA. All cells require a multiprotein DNA duplication system (replisomes) for their existence. However, death of normal cells in our body occurs through the apoptotic process. During apoptotic process several crucial genes are dow...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Publication date: Available online 14 January 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Nancy Dumont, Samantha Merrigan, Jason Turpin, Cynthia Lavoie, Vasilios Papavasiliou, Elena Geretti, Christopher Espelin, Lia Luus, Walid Kamoun, Omid Ghasemi, G. Gary Sahagian, William Muller, Bart Hendriks, Thomas J. Wickham, Daryl C. DrummondAbstractMM-302 is an anti-HER2 antibody-targeted pegylated liposomal doxorubicin designed to deliver doxorubicin specifically to HER2-expressing solid tumors. The delivery and activity of MM-302 was evaluated in orthotopic, transgenic, and intravenous breast cancer ...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
Conditions:   Anatomic Stage IV Breast Cancer AJCC v8;   Breast Carcinoma Metastatic in the Brain;   Estrogen Receptor Positive;   HER2/Neu Negative;   Metastatic Breast Carcinoma;   Postmenopausal;   Prognostic Stage IV Breast Cancer AJCC v8 Interventions:   Drug: Copanlisib;   Drug: Fulvestrant Sponsor:   National Cancer Institute (NCI) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract BACKGROUND: Brain metastases (BM) are a rare but devastating condition in estrogen receptor (ER)- positive metastatic breast cancer (MBC). While endocrine therapy (ET) is the mainstay of treatment in this disease subtype, only case reports have been published concerning the activity of ET in BM henceforth. Therefore, we aimed to systematically investigate the impact of ET after diagnosis of BM on outcome and clinical course of disease in patients with ERpositive MBC. PATIENTS AND METHODS: Patient characteristics, detailed information about BM including diagnosis specific graded prognostic assessment ...
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
Four months ago I was diagnosed with breast cancer. Since then, I’ve had biopsies, a mastectomy, lymph node removals, countless scans and blood tests, an imminent death scare and two rounds of chemotherapy. Today, I’ll be having my third round and by rights I should be feeling terrified. Chemo’s pretty toxic – my oncologist told me semi-jokingly that the aim is to get as close to killing me as possible. But I don’t feel scared – I’m feeling calm and secure. This is because, thanks to the NHS team at south London’s St George’s hospital, a trip to the chemo ward feels as ...
Source: UNISON Health care news - Category: UK Health Authors: Tags: Article Magazine cancer NHS Source Type: news
CONCLUSION: This work makes it possible to harmonize the delineation practices around validated standards. An extension to the entire Hauts-de-France region is planned. PMID: 30639377 [PubMed - as supplied by publisher]
Source: Cancer Radiotherapie - Category: Cancer & Oncology Authors: Tags: Cancer Radiother Source Type: research
We describe a case of 47-year-old woman affected by human epidermal growth factor receptor-2–positive breast cancer with a diffuse leptomeningeal carcinomatosis. An intense uptake of 18F-choline was reported at fused PET/MRI images in the brain, compatible with a diffuse leptomeningeal disease. This case highlights that 18F-choline PET would be used for the identification of leptomeningeal involvement in patients affected by breast cancer, as a support of MRI images.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
Conditions:   Anatomic Stage IV Breast Cancer AJCC v8;   Astrocytoma;   Breast Carcinoma Metastatic in the Brain;   Glioma;   Invasive Breast Carcinoma;   Oligodendroglioma;   Prognostic Stage IV Breast Cancer AJCC v8;   Recurrent Glioma Interventions:   Other: Best Practice;   Drug: Ketoconazole Sponsors:   Wake Forest University Health Sciences;   National Cancer Institute (NCI) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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