Cancer Immunotherapy Trials Underutilize Immune Response Monitoring

We report the results from a cross‐sectional analysis of response monitoring in 685 T‐cell checkpoint‐targeted cancer immunotherapy trials in solid malignancies, as registered on the U.S. National Institutes of Health trial registry by October 2016. Immune‐related radiological response criteria were registered for only 25% of clinical trials. Only 38% of trials registered an exploratory immunological biomarker, and registration of immunological biomarkers has decreased over the last 15 years. We suggest that increasing the utilization of immune‐related response monitoring across cancer immunotherapy trials will improve analysis of outcomes and facilitate translational efforts to extend the benefit of immunotherapy to a greater proportion of patients with cancer.

Source: The Oncologist - January 9, 2018 Category: Cancer & Oncology Authors: Claire M. Connell, Sophie E.M. Raby, Ian Beh, Thomas R. Flint, Edward H. Williams, Douglas T. Fearon, Duncan I. Jodrell, Tobias Janowitz Tags: New Drug Development and Clinical Pharmacology, Precision Medicine Brief Communications Source Type: research