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Sarcopenia Is Associated with Quality of Life and Depression in Patients with Advanced Cancer

AbstractBackground.Patients with advanced cancer often experience muscle wasting (sarcopenia), yet little is known about the characteristics associated with sarcopenia and the relationship between sarcopenia and patients’ quality of life (QOL) and mood.Materials and Methods.As part of a randomized trial, we assessed baseline QOL (Functional Assessment of Cancer Therapy‐General [FACT‐G]) and mood (Hospital Anxiety and Depression Scale [HADS]) in patients within 8 weeks of diagnosis of incurable lung or gastrointestinal cancer, and prior to randomization. Using computed tomography scans collected as part of routine clinical care, we assessed sarcopenia at the level of the third lumbar vertebra with validated sex‐specific cutoffs. We used logistic regression to explore characteristics associated with presence of sarcopenia. To examine associations between sarcopenia, QOL and mood, we used linear regression, adjusted for patients’ age, sex, marital status, education, and cancer type.Results.Of 237 participants (mean age = 64.41 ± 10.93 years), the majority were male (54.0%) and married (70.5%) and had lung cancer (56.5%). Over half had sarcopenia (55.3%). Older age (odds ratio [OR] = 1.05, p = .002) and education beyond high school (OR = 1.95, p = .047) were associated with greater likelihood of having sarcopenia, while female sex (OR = 0.25, p 
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Symptom Management and Supportive Care Source Type: research

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Conclusions Sedentary time and light intensity physical activity were significantly associated with some psychosocial health outcomes. Reducing sedentary time and increasing light intensity physical activity may be a more appropriate recommendation for many lung cancer survivors given their older age, poorer functional status, and reduced pulmonary capacity.
Source: Mental Health and Physical Activity - Category: Psychiatry & Psychology Source Type: research
The cover image, by Ju Youn Jung et al., is based on the Paper Comparison of fatigue, depression, and anxiety as factors affecting posttreatment health‐related quality of life in lung cancer survivors, DOI 10.1002/pon.4513.
Source: Psycho-Oncology - Category: Cancer & Oncology Authors: Tags: COVER IMAGE Source Type: research
CONCLUSION Cognitive impairment can affect daily functioning, quality of life, and capacity to work in patients with cancer and those in remission. Consequently, cognitive assessment is now an important and necessary part of a comprehensive oncological care plan. Cancer-related cognitive impairment might be due to the direct effects of the cancer itself, nonspecific factors, or comorbid conditions that are independent of the disease and/or due to the adverse effects of the treatment or combination of treatments given for the disease. The prevalence and extent of cognitive impairment associated with cancer is recognized but...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Cognition Current Issue Neuro oncology Neurology Review cancer chemotherapy cognitive impairment neuropsychological assessment treatment Source Type: research
This study will assess the effect of group TCC in postsurgery NSCLC survivors on VO2peak, lung function, and other aspects. The results of this study will eventually provide clinical proof of the application of TCC as one kind of exercise training for patients across the entire NSCLC continuum, as well as information on the safety and feasibility of exercise.Trial RegistrationChinese Clinical Trial Registry:ChiCTR-IOR-15006548. Registered on 12 June 2015.
Source: Trials - Category: Research Source Type: clinical trials
ConclusionsA large proportion of family caregivers, including those experiencing depression and anxiety symptoms and who were underprepared, are not using formal support services but have a strong interest in services. Strategies to increase service use may include targeting distressed caregivers early in their caregiving experience.
Source: Psycho-Oncology - Category: Cancer & Oncology Authors: Tags: PAPER Source Type: research
The aim of the study is researching the correlation between fatigue and muscle strength, anxiety, depression, quality of life at lung cancer patients. 9 patients (5 female, 4 male) who were treating in Hacettepe University Oncology Hospital participated in the study. Brief Fatigue Inventory was used to determine fatigue level. Shoulder flexion, elbow flexion, hip flexion, knee extension were evaluated with j tech hand held dynamometer. Grip strength of both hands were evaluated with jamar hand dynamometer in sitting position. The anxiety levels were assessed with Hospital Anxiety and Depression Inventory and the quality of...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
Conclusion: Patients with lung cancer and comorbid hypertension had poorer functional exercise capacity than those without hypertension, despite similar symptoms of anxiety and depression, and quality of life. Hypertension in these patients seems to affect physical performance outcomes more than psychological outcomes.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Physiotherapists Source Type: research
Conclusion: A 7 weeks / 20 sessions outpatient PR program have significant positive impact in terms of quality of life, exercise tolerance, dyspnea and psychological status in patients with COPD and lung resection for cancer.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Rehabilitation and Chronic Care Source Type: research
Introduction: Lung cancer is the most common cause of death among all malignant neoplasm in men. Most of lung cancer patients are diagnosed in advanced stage, which requiers different treatment modalities (chemotherapy and/or radiotherapy) and has a high mortality rate. Some studies suggest that initial Quality of Life (QOL) is a strong prognostic factor for survival in lung cancer. Proper evaluation of QOL leads to improvement of QLL, especially in patients with terminal stage illness, and is an important part of supportive and palliative management of these patients.Aims and Objectives: To examine the initial QOL in newl...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Epidemiology Source Type: research
Background/Objective. Cancer is a major stress and traumatic factor for every individual, leading to psychological distress in over 50% of the patients.1 Thus, studies that approached the coping problem in patients with cancer appeared. We aimed to analyze the coping style and its stability in time in patients with lung cancer and to evaluate the intensity of anxiety and depression before and after receiving the diagnosis.Methods: Before receiving the diagnosis and after one month patients completed the COPE scale, Generalized Anxiety Disorder Questionnaire (GAD-7) and Patient Health Questionnaire-9 (PHQ-9). A comparison w...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Others Source Type: research
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