Screening, Treatment Cuts Breast Cancer Deaths in Half

Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Family Medicine, Nursing, Oncology, Radiology, Research, Preventive Medicine, News, Source Type: news

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TP53 upregulates α‑smooth muscle actin expression in tamoxifen‑resistant breast cancer cells. Oncol Rep. 2018 Dec 06;: Authors: Kim S, You D, Jeong Y, Yu J, Kim SW, Nam SJ, Lee JE Abstract In a previous study, we reported that α‑smooth muscle actin (α‑SMA), one of the mesenchymal marker proteins, is highly expressed in tamoxifen‑resistant breast cancer (TamR) cells. However, the exact mechanism of α‑SMA expression in TamR cells is not fully understood. Here, we investigated the effect of TP53 on α‑SMA expression in breast cancer cells. The levels of α...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
MAPT (Tau) expression is a biomarker for an increased rate of survival for low‑grade glioma. Oncol Rep. 2018 Nov 28;: Authors: Zaman S, Chobrutskiy BCI, Sikaria D, Blanck G Abstract The association of MAPT (Tau) with various tauopathies and other neurological disorders has long been established. However, the role of microtubule‑associated protein Tau (MAPT) expression in brain cancer is largely unknown. To determine whether MAPT expression is related to low‑grade glioma (LGG) survival rates, RNASeq data representing samples from the Cancer Genome Atlas (TCGA) were assessed. Results revealed that ...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
This article reviews current endocrine treatment strategies and recent and ongoing studies of combination therapies in metastatic hormone receptor-positive, HER2-negative breast cancer. PMID: 30538108 [PubMed - in process]
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
Conclusion: The results of our study demonstrate a high effectiveness of ECT in the treatment of cutaneous metastasis from breast cancer. This method, although used for palliative treatment, brings a significant improvement in the quality of life of patients.Oncol Res Treat
Source: Oncology Research and Treatment - Category: Cancer & Oncology Source Type: research
Publication date: Available online 13 December 2018Source: Journal of Geriatric OncologyAuthor(s): Andrea Sitlinger, Rebecca A. Shelby, Alyssa N. Van Denburg, Heidi White, Sarah N. Edmond, Paul K. Marcom, Hayden B. Bosworth, Francis J. Keefe, Gretchen G. KimmickAbstractObjectiveTo explore the impact of symptoms on physical function in women on adjuvant endocrine therapy for breast cancer.MethodsEligible women were postmenopausal, had hormone receptor positive, stage I-IIIA breast cancer, completed surgery, chemotherapy, radiation, and on adjuvant endocrine therapy. At a routine follow-up visit, women (N = 107) complete...
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
Dr. Lewis Cantley discusses targeting the PI3K pathway in breast cancer and the importance of managing ambient insulin levels during therapy.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
Conclusion: High PGK1 expression was associated with poor prognosis in breast cancer, because PGK1 and HIF-1 α formed a positive feed-forward loop and thus stimulated breast cancer progression and metastases. Based on these results, PGK1 may serve as a promising biomarker and target therapy for breast cancer.Cell Physiol Biochem 2018;51:2434 –2444
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
Marzio et  al. report that cellular levels of RAD51 are kept in check by EMI1-mediated degradation. Upon DNA damage, CHK1 phosphorylation of RAD51 on Thr309 counteracts this event, allowing RAD51 accumulation and HRR. Downregulation of EMI1 in BRCA1-deficient breast cancer cells induces primary and acquired resistance to PARPi both in vitro and in vivo.
Source: Molecular Cell - Category: Cytology Authors: Tags: Article Source Type: research
Postmenopausal women with higher body fat levels may be at increased risk for breast cancer, even if their body mass index (BMI) is normal, researchers say.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Medscape Today News Source Type: news
Peter Schmid, the'Most Popular Man in San Antonio,'discusses the long-awaited results of IMpassion130, the ground-breaking trial evaluating immunotherapy for metastatic triple-negative breast cancer.Medscape Oncology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Hematology-Oncology Commentary Source Type: news
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