Vitamins in Pregnancy May Lower Autism Risk Vitamins in Pregnancy May Lower Autism Risk

Children of mothers who took folic acid or multivitamins before or during pregnancy were at lower risk for autism spectrum disorder, researchers say, but more research is needed.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Psychiatry News Source Type: news

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BOSTON (CBS) – The health of a mother’s gut may affect her child’s risk of developing autism. That’s according to a new study from the University of Virginia School of Medicine. The microbiome is the collection of organisms that live in all of us, like in our guts and on our skin. In recent years, scientists have discovered that having a healthy microbiome not only helps keep your gut healthy but also supports your immune system and can help prevent a variety of disorders. Now based on studies in rodents, researchers believe that an unhealthy microbiome in a mom’s gut while pregnant can make a...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Healthwatch Syndicated Local Autism Dr. Mallika Marshall Local TV Microbiome Source Type: news
AbstractThe aim of this study is to understand the association between prenatal, newborn and postnatal head circumference (HC) and preschool neurodevelopment in a large population-based birth cohort. The INMA project followed 1795 children from 12  weeks of pregnancy to preschool years. HC measurements were carried out prospectively, and following a standardized protocol during pregnancy (12, 20 and 34 weeks), birth, and child ages of 1–1.5 and 4 years old; andz-scores were further estimated. Prenatal head growth was assessed using conditionalz-scores between weeks 12 –20 and 20–34. Several...
Source: European Child and Adolescent Psychiatry - Category: Psychiatry Source Type: research
Authors: Hamzawy MA, El-Ghandour YB, Abdel-Aziem SH, Ali ZH Abstract The aspect of treatment of autistic behaviour was investigated using valproic acid rat model of pregnant female rats. Two main groups (10 male rats/group) were treated for 6 days and then divided into six subgroups. The first group of normal rats was divided into three subgroups: (A) - control group, (B) - treated with camel milk (CAM; 2 mL/p.o) and (C) - treated with leptin (1000 µg/kg i.p) twice daily. The second group of autistic rats was randomly distributed into four subgroups as follows: (D) - positive control (autistics rats), ...
Source: International Journal of Immunopathology and Pharmacology - Category: Allergy & Immunology Tags: Int J Immunopathol Pharmacol Source Type: research
In conclusion, a dysregulated placental immune response may provide a plausible mechanism for both the epidemiological links between DVD-deficiency and increased male incidence of developmental conditions such as autism.
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
Publication date: Available online 31 May 2018Source: Reproductive ToxicologyAuthor(s): Asher Ornoy, Gideon Koren, Joseph YanaiAbstractWe discuss the possibilities to prevent the post-exposure teratogenic effects of several teratogens: valproic acid (VPA), diabetes and alcohol. Co-administration of folic acid with VPA reduced the rate of Neural Tube Defects (NTD) and other anomalies in rodents, but apparently not in pregnant women. Antioxidants or the methyl donor S-adenosyl methionine prevented Autism Spectrum Disorder (ASD) like behavior in mice and rats. In vivo and in vitro studies demonstrated that antioxidants, arach...
Source: Reproductive Toxicology - Category: Toxicology Source Type: research
Publication date: Available online 14 May 2018Source: Brain, Behavior, and ImmunityAuthor(s): Ruthy Glass, Sara Norton, Nicholas Fox, Alexander W. KusnecovAbstractStimulation of the immune system during pregnancy, known as maternal immune activation (MIA), can cause long-lasting neurobiological and behavioral changes in the offspring. This phenomenon has been implicated in the etiology of developmental psychiatric disorders, such as autism and schizophrenia. Much of this evidence is predicated on animal models using bacterial agents such as LPS and/or viral mimics such as Poly I:C, both of which act through toll-like recep...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Publication date: Available online 5 May 2018Source: Brain, Behavior, and ImmunityAuthor(s): Tamara S. Bodnar, Charlis Raineki, Wladimir Wertelecki, Lyubov Yevtushok, Larisa Plotka, Natalya Zymak-Zakutnya, Gordon Honerkamp-Smith, Alan Wells, Matthieu Rolland, Todd S. Woodward, Claire D. Coles, Julie A. Kable, Christina D. Chambers, Joanne Weinberg, Collaborative Initiative on Fetal Alcohol Spectrum Disorders (CIFASD)AbstractCytokines and chemokines are potent modulators of brain development and as such, dysregulation of the maternal immune system can result in deviations in the fetal cytokine balance, altering the course o...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Publication date: 30 August 2018Source: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 86Author(s): Michael Davidovitch, Gabriel Chodick, Varda Shalev, Vered H. Eisenberg, Uzi Dan, Abraham Reichenberg, Sven Sandin, Stephen Z. LevineAbstractWe aimed to examine the effects of infertility treatments on the risk of Autism Spectrum Disorder (ASD). Data were from a representative national registry on 110,093 male live births in Israel (born: 1999–2008; and ASD: 975, 0.9%). Infertility treatments included In Vitro Fertilization (IVF), and five hormone treatments. Relative risk (RR) was estimated with...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
In this study, we have investigated ER stress condition and neuronal maturation in an ASD mice model employing male ICR mice.An ASD mice model was established by injecting with valproic acid (VPA) into pregnant mice. The offspring born from VPA-treated mothers were subjected to the experiments as the ASD model mice. The cerebral cortex and hippocampus of ASD model mice were found to be under high ER stress. The mRNA levels of Hes1 and Pax6 were decreased in the cerebral cortex of the ASD model mice, but not in the hippocampus. In addition, the mRNA level in Math1 was increased in the cerebral cortex. ER stress inhibited de...
Source: Neurochemistry International - Category: Neuroscience Source Type: research
CONCLUSION: We propose that the large inconsistencies in findings among studies in the field are due to differences in subdiagnoses among the included children with ASD. Well-phenotyped ASD samples are needed to understand the biological and immunological mechanisms underpinning ASD and its subdiagnoses. Future research should apply new strategies to scrutinize the link between ASD and changes in immune responsivity. Important new research avenues are to investigate the associations (a) between different ASD phenotypes and aberrations in (auto)immune pathways and (b) between reduced natural regulatory autoimmune responses ...
Source: CNS and Neurological Disorders Drug Targets - Category: Drugs & Pharmacology Authors: Tags: CNS Neurol Disord Drug Targets Source Type: research
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