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Vitamins in Pregnancy May Lower Autism Risk Vitamins in Pregnancy May Lower Autism Risk

Children of mothers who took folic acid or multivitamins before or during pregnancy were at lower risk for autism spectrum disorder, researchers say, but more research is needed.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Psychiatry News Source Type: news

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(Wiley) During pregnancy, use of the antiepileptic drug valproic acid has been associated with worse outcomes -- including fetal loss, impaired growth, major congenital malformations, increased risk of developmental problems, and autism -- compared with all other antiepileptic drugs.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
RESUMO Os autores relatam um caso da enfermaria psiqui átrica do Hospital Geral Santa Casa de Misericórdia de Sorocaba-SP. Paciente gestante, de 19 anos, usuária crônica de maconha que apresenta náuseas e vômitos intensos não responsivos aos antieméticos, associados a dor abdominal, agitação psicomotora e hábito compulsivo de tomar banhos que ntes para alívio dos sintomas, quadro que caracteriza a SHC. Trata-se de uma síndrome rara, com efeito paradoxalmente emetogênico da maconha. É subdiagnosticada e relacionada ao uso c...
Source: Jornal Brasileiro de Psiquiatria - Category: Psychiatry Source Type: research
There’s a growing and confusing group of studies looking at the effect of anti-depressants during pregnancy. Some research suggests that the drugs are linked to an increased risk of miscarriage, while other studies focus on the implications for the developing baby (including possible birth defects and an increased risk of autism), while other studies questioned such associations. So it’s not surprising that doctors and expectant moms struggle with weighing the benefits of treating the mother’s depression with an incomplete understanding of the risks involved. In the latest study to address the subject, re...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Antidepressants Brain Reproductive Health ssris Source Type: news
Accumulating evidence points to a central role for immune dysregulation during pregnancy as a risk factor in Autism Spectrum Disorder (ASD). Human epidemiological studies suggest that maternal viral infections early in pregnancy correlate with an increased frequency of ASD. This observation, coined maternal immune activation (MIA), has been modeled in rodents by inducing inflammation in pregnant dams. However, the immune cell populations critical in the MIA model have not been identified. We hypothesize Th17 cells and commensal bacteria inducing them in pregnant mice contribute to the development of MIA-associated phenotypes in offspring.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research
Prenatal exposure to certain medications has been hypothesized to influence the risk of autism spectrum disorder (ASD). However, safety of the majority of pharmaceuticals has not been verified. We investigated the effects of all medications acting on the major neurotransmitter systems, and taken by pregnant women in our sample, on the risk of ASD in offspring.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research
Contributors : Diane I Schroeder ; Janine M LaSalleSeries Type : Methylation profiling by high throughput sequencingOrganism : Homo sapiensEpigenetic perturbations in the early embryo could have later effects during development. For a disease such as autism, where a diagnosis is hard before two years of age but earlier intervention is correlated with better outcomes, finding a molecular signature of the disease at birth could have a significant impact of the quality of life. Since placenta also derives from the early embryo, is a readily-available tissue at birth, and has a unique DNA methylation pattern, we tested whether...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Methylation profiling by high throughput sequencing Homo sapiens Source Type: research
ConclusionsThe presented clinical case is worthy of note since the observed microdeletion is often associated with a clinical phenotype tending to overweightness, but the proband (female) was hospitalized due to poor height and weight development, and anorexia. Moreover, the segregant nature of the observed genomic abnormality has to be noted, as well as the phenotypic variability between the mother and daughter. The case described here enriches the phenotypical spectrum linked to the 16p11.2 microdeletion. For these reasons, in the presence of a suspected genetic pathology it is fundamental to study the proband from the c...
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
CONCLUSIONS: Abnormal maternal thyroid function in early pregnancy was associated with epilepsy, ASD, and ADHD in the child, but associations differed by subtypes of exposure and by child age and sex. More evidence on subtypes and severity of maternal thyroid function is needed, and alternative outcomes of child neurodevelopment may be warranted. PMID: 29584590 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
(McLean Hospital) McLean Hospital neuroscientists have found that immune system activation during pregnancy and right at birth can cause alterations in the brain's neural circuits during young adulthood that are consistent with behavioral symptoms common in autism spectrum disorder (ASD) and other developmental conditions.
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news
CONCLUSIONS: Our data suggest that children with ASDs may have defects in folic acid absorption that play a role in the onset of ASDs. PMID: 29578363 [PubMed - as supplied by publisher]
Source: Biomarkers - Category: Research Tags: Biomarkers Source Type: research
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