Vitamins in Pregnancy Linked to Less Autism in Offspring Vitamins in Pregnancy Linked to Less Autism in Offspring

Children of mothers who took folic acid or multivitamins before or during pregnancy were at lower risk for autism spectrum disorder, researchers say, but more research is needed.Medscape Medical News
Source: Medscape Psychiatry Headlines - Category: Psychiatry Tags: Psychiatry News Source Type: news

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AbstractAutism spectrum disorder is a neurodevelopmental disorder and the cause of autism is still unclear. The aim of this study was to investigate the association of socioeconomic, environmental, pregnancy and newborn-related risk factors among children with autism spectrum disorders. This was a population-based case –control study. The study included 55 children with autism spectrum disorder and 55 age and sex matched typically developing normal children (TD) between 3 and 12 years. Several socio-economic factors, environmental factors, pregnancy related, natal, post-natal factors and the first noticed signs ...
Source: Acta Neurologica Belgica - Category: Neurology Source Type: research
Maternal use of medicines targeting neurotransmitter systems is unlikely to directly affect the risk of autism spectrum disorder in offspring, the authors of a study published in JAMA Psychiatry have concluded.
Source: Clinical Pharmacist - Category: Drugs & Pharmacology Source Type: research
ConclusionsOur data on the microbiota of the VPA rat model of autism indicate that this model, in addition to behaviorally and anatomically mimicking the autistic brain as previously shown, also mimics the microbiome features of autism, making it one of the best-suited rodent models for the study of autism and ASD.
Source: Molecular Autism - Category: Molecular Biology Source Type: research
Abstract Autism spectrum disorder (ASD) is a common neuropsychiatric disorder, which is characterized by impairment in social interaction and cognitive behaviors. However, there is not much electrophysiological data available on alterations of neuronal excitability in autism. Here, we assessed the pattern of neuronal excitability and the possible contribution of Ih current to the altered excitability of hippocampal CA1 pyramidal neurons in a rat model of VPA-induced ASD-like behavior. Pregnant Wistar rats received Valproic Acid (VPA, 500mg/kg) at gestational day 12.5. All offspring were subjected to behavioral tes...
Source: Brain Research - Category: Neurology Authors: Tags: Brain Res Source Type: research
CONCLUSION: Ob-gyns perceive vaccine refusal among pregnant women as common and refusal of influenza vaccine as more common than refusal of Tdap vaccine. Emphasizing the risk of disease to the fetus or newborn may be an effective strategy to increase vaccine uptake. PMID: 30531564 [PubMed - as supplied by publisher]
Source: Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Obstet Gynecol Source Type: research
The objectives of this study were to determine whether high-resolution metabolomics is able to link the metabolite profile of PWWE receiving lamotrigine or levetiracetam for seizure control to associated pharmacodynamic (PD) biological responses. Untargeted metabolomic analysis of plasma obtained from 82 PWWE was completed using high-resolution mass spectrometry. Biological alterations due to lamotrigine or levetiracetam monotherapy were determined by a metabolome-wide association study that compared patients taking either drug to those who did not require AED treatment. Metabolic changes associated with AED use were then ...
Source: Toxicology and Applied Pharmacology - Category: Toxicology Authors: Tags: Toxicol Appl Pharmacol Source Type: research
Source: Clinical Epidemiology - Category: Epidemiology Tags: Clinical Epidemiology Source Type: research
Maternal smoking during pregnancy and autism: using causal inference methods in a birth cohort study, Published online: 29 November 2018; doi:10.1038/s41398-018-0313-5Maternal smoking during pregnancy and autism: using causal inference methods in a birth cohort study
Source: Translational Psychiatry - Category: Psychiatry Authors: Source Type: research
AbstractStudies have examined the association between parental body mass index (BMI) and autism spectrum disorder (ASD) in offspring, with inconsistent results, especially regarding maternal obesity, overweight and underweight. Cochrane Library, EMBASE, PubMed and PsycINFO databases were searched up to March 2018 for relevant observational studies with no language restriction. Our literature search identified 13 eligible studies for meta-analysis (involving 943,293 children and 30,337 cases). For maternal BMI (13 studies), both maternal obesity [OR 1.41 (95% CI 1.19 –1.67)] and maternal overweight [OR 1.16 (95% CI 1....
Source: European Child and Adolescent Psychiatry - Category: Psychiatry Source Type: research
To test the hypothesis that a pregnancy infection increases risk for the fetus of a broad spectrum of psychopathologies including psychosis, depression, bipolar disorder and autism in childhood and adulthood.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: IDSOG Abstract Source Type: research
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