The bone-marrow niche in MDS and MGUS: implications for AML and MM

The bone-marrow niche in MDS and MGUS: implications for AML and MMThe bone-marrow niche in MDS and MGUS: implications for AML and MM, Published online: 09 January 2018; doi:10.1038/nrclinonc.2017.197Both multiple myeloma and acute myeloid leukaemia are often preceded by defined precursor stages of neoplasia, which can aid efforts to unravel the mechanisms of disease progression. Herein, the authors review studies of the important roles of microenvironmental factors in promoting the development and progression of haematological cancers in these precursor conditions. Potential therapeutic strategies targeting the abnormal bone-marrow microenvironment are discussed.

Source: Nature Clinical Practice Oncology - January 9, 2018 Category: Cancer & Oncology Authors: Irene M. Ghobrial Alexandre Detappe Kenneth C. Anderson David P. Steensma Source Type: research