Medical Treatment of Pulmonary Arterial Hypertension Medical Treatment of Pulmonary Arterial Hypertension
Get up-to-date on the latest treatment strategies for pulmonary arterial hypertension.Seminars in Respiratory and Critical Care Medicine
Authors: Osińska AN, Begier-Krasińska B, Rzymski P, Krasińska A, Tykarski A, Krasiński Z Abstract Introduction: Arterial hypertension (HT) is one of the most common diseases around the world and constitutes a significant medical, social, and economic problem. Lifestyle changes, including adequate fruit and vegetable consumption, play an important role in controlling blood pressure (BP) and other cardiovascular risk factors. Aim: To compare the influence of adding acetylsalicylic acid (ASA) or standardized tomato extract (STE) to standard hypotensive therapy on the values of arterial pressure and the daily blood...
Conclusion: Hypertension-induced renal injury in SHR may be alleviated by DHI in part by local suppression of Kidney injury molecule-1 and down-regulation of Myoglobin. However, if this effect is independent of the known anti-hypertensive action of DHI in blood vessel remains to be determined.Kidney Blood Press Res 2018;43:12 –24
Conclusion: We hereby firstly report significant total body and skin chloride retention in salt sensitive hypertension of GDNF+/-mice with genetically determined lower nephron number. Thus, in contrast to the prevailing opinion our data argue for the involvement of non-volume related mechanisms.Kidney Blood Press Res 2018;43:1 –11
A new editorial from the American College of Cardiology pushes back against the new hypertension guidelines released in 2017.
Abstract Pulmonary vascular remodeling is the main pathological hallmark of pulmonary hypertension disease. We undertook a comprehensive and multilevel approach to investigate the origin of smooth muscle actin‐expressing cells in remodeled vessels. Transgenic mice that allow for specific, inducible and permanent labeling of endothelial (Cdh5‐tdTomato), smooth muscle (Acta2‐, Myh11‐tdTomato), pericyte (Cspg4‐tdTomato) and fibroblast (Pdgfra‐tdTomato) lineages were used to delineate the cellular origins of pulmonary vascular remodeling. Mapping the fate of major lung resident cell types revealed smooth muscle cel...
Conclusions: For the first time, this prospective study provided the current prevalence of NTDT related complications in a Southeast Asian population with a different underlying genetic basis compared with previous studies. Although individual prevalence of each complication might differ from other studies, several important clinical factors such as splenectomy, degree of anemia, and iron overload seem to be determining risks of developing these complications consistently across different ethnicities. This article is protected by copyright. All rights reserved.
ConclusionsPatients undergoing liver transplant are more prone to experience diabetes, hypertension or dyslipidaemia, and NAFLD may be an important element in this context. In this study, we show how the prevalence of NASH tends to remain significant and similar to the general population. Moreover, this study suggests a possible association with specific transplant indications. Further studies are required to confirm these findings.
ConclusionsThese findings suggest that TRPV3 is involved in hypoxia‐induced pulmonary vascular remodeling and promotes proliferation of PASMCs and the effect is, at least in part, mediated via the PI3K/AKT pathway.
To explore whether five variables of the health belief model were factors influencing self-care behaviors in young and middle-aged adults with hypertension.
AimTo describe presentation, clinical course, and outcome in postneonatal presentations of vein of Galen malformation (VGM). MethodChildren older than 28 days presenting with VGM (from 2006–2016) were included. Notes/scans were reviewed. Outcome was dichotomized into ‘good’ or ‘poor’ using the Recovery and Recurrence Questionnaire. Logistic regression was performed to explore relationships between clinico‐radiological features and outcome. ResultsThirty‐one children (18 males, 13 females) were included, presenting at a median age of 9.6 months (range 1.2mo–11y 7mo), most commonly wit...