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Risk Factors for Ventilator-Associated Events in a PICU*

Objective: The term ventilator-associated events includes ventilator-associated condition, infection-related ventilator-associated complication, and ventilator-associated pneumonia. We sought to identify potential new risk factors for ventilator-associated condition and infection-related ventilator-associated complication in the PICU population. Design: Matched case control study. Setting: Children’s hospital at a tertiary care academic medical center. Patients: During the study period, 606 patients were admitted to PICU and ventilated more than 48 hours; 70 children met ventilator-associated condition criteria. Interventions: None. Measurements and Main Results: We applied the definition for ventilator-associated condition (i.e., a sustained increase in ventilator settings after a period of stable or decreasing support) to our database. Within ventilator-associated condition cases, 40 cases were infection-related ventilator-associated complication and 30 cases were noninfectious-related ventilator-associated condition. We identified 140 controls and matched to ventilator-associated condition cases with regard to age, immunocompromised status, and ventilator days to event. Patients with ventilator-associated condition had longer ICU stay versus controls; 24 days median (12–43 interquartile range) versus 7 days (4–14); (p
Source: Pediatric Critical Care Medicine - Category: Pediatrics Tags: Online Clinical Investigations Source Type: research

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Conditions:   Community-acquired Pneumonia;   Hospital-acquired Pneumonia Interventions:   Drug: Ceftobiprole medocaril;   Drug: Ceftazidime;   Drug: Ceftriaxone Sponsor:   Basilea Pharmaceutica Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Pharmacokinetics;   Critical Illness Intervention:   Sponsors:   Universitaire Ziekenhuizen Leuven;   Katholieke Universiteit Leuven Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Li N, Duan Q, Zhang W Abstract The risk factors and coping strategies of severe community-acquired pneumonia (SCAP) in chemotherapy induction period of acute leukemia were investigated. Eighty-six patients with CAP in chemotherapy induction period of acute leukemia in Dezhou Hospital from March 2014 to February 2017 were selected and divided into observation group (SCAP group, n=45) and control group (non-SCAP group, n=41) according to the acute physiology and chronic health evolution II (APACHE II) score. The blood, sputum, nasopharyngeal secretion and pleural effusion samples were collected from patients...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
MEASLES cases in Europe have surged over the last year, with large outbreaks affecting one in four countries. Symptoms usually develop around 10 days after infection, and in some cases, the highly infectious viral illness can lead to brain damage, death and pneumonia. Dr Chris Steele urged parents on This Morning to get their children vaccinated before travelling to Europe.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
We present the case of a 45 year old woman with acute Q fever pneumonia who progressed to the chronic phase of the disease despite azithromycin therapy. A trial of doxycycline was halted because of severe allergy and she was put on clarithromycin and later moxifloxacin. Failure of both drugs required desensitization to doxycycline with escalating doses. After two-year treatment with doxycycline-hydroxychloroquine combination, complete recovery was declared. Our case highlights the option of doxycycline desensitization when an acute allergic reaction poses an obstacle to optimal treatment.
Source: IDCases - Category: Infectious Diseases Source Type: research
Actinobacillus pleuropneumoniae is the causative agent of porcine contagious pleuropneumonia. Overproduction of proinflammatory cytokines, like interleukin-1β (IL-1β), IL-6, tumor necrosis factor alpha, and resistin, in the lung is an important feature of A. pleuropneumoniae infection. These proinflammatory cytokines enhance inflammatory and immunological responses. However, the mechanism that leads to cytokine production remains unclear. As a major virulence factor of A. pleuropneumoniae, lipopolysaccharide (LPS) may act as a potent stimulator of Toll-like receptor 4 (TLR4), triggering a number of intracellular ...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Cellular Microbiology: Pathogen-Host Cell Molecular Interactions Source Type: research
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
ConclusionRisk of hospital readmission associated with dementia varied according to primary diagnosis. Healthcare providers could enforce interventions to minimize readmission by focusing on comorbid conditions in individuals with dementia and specific primary diagnoses that increase their risk of readmission.
Source: Journal of the American Geriatrics Society - Category: Geriatrics Authors: Tags: Clinical Investigation Source Type: research
Streptococcus pneumoniae is a frequent colonizer of the upper respiratory tract and a leading cause of bacterial pneumonia. The innate immune system senses pneumococcal cell wall components, toxin, and nucleic acids, which leads to production of inflammatory mediators to initiate and control antibacterial defense. Here, we show that the cGAS (cyclic GMP-AMP [cGAMP] synthase)-STING pathway mediates detection of pneumococcal DNA in mouse macrophages to primarily stimulate type I interferon (IFN) responses. Cells of human individuals carrying HAQ TMEM173, which encodes a common hypomorphic variant of STING, were largely or pa...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Host Response and Inflammation Source Type: research
Statistics indicate as many as 24 percent of Alzheimer's patients wake up caregivers at night and have trouble sleeping.By Bob DeMarcoAlzheimer's Reading RoomRecently I received several emails about sleeping problems.Specifically, about Alzheimer's patients staying up at night, or Alzheimer's patients waking up the caregiver at night.Some doctors recommend antipsychotic medications for this problem.This is completely inappropriate and should be avoided. See -Antipsychotic Medications Linked to Increased Risk of Pneumonia in Alzheimer ’s Patients.Sleep Medications for Alzheimer's and Dementia PatientsStatistics indica...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: alzheimer's care Alzheimer's Dementia alzheimer's sleep dementia care dementia help for caregivers family caregiving help alzheimer's help with dementia care memory care Source Type: blogs
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