Risk Factors for Ventilator-Associated Events in a PICU*

Objective: The term ventilator-associated events includes ventilator-associated condition, infection-related ventilator-associated complication, and ventilator-associated pneumonia. We sought to identify potential new risk factors for ventilator-associated condition and infection-related ventilator-associated complication in the PICU population. Design: Matched case control study. Setting: Children’s hospital at a tertiary care academic medical center. Patients: During the study period, 606 patients were admitted to PICU and ventilated more than 48 hours; 70 children met ventilator-associated condition criteria. Interventions: None. Measurements and Main Results: We applied the definition for ventilator-associated condition (i.e., a sustained increase in ventilator settings after a period of stable or decreasing support) to our database. Within ventilator-associated condition cases, 40 cases were infection-related ventilator-associated complication and 30 cases were noninfectious-related ventilator-associated condition. We identified 140 controls and matched to ventilator-associated condition cases with regard to age, immunocompromised status, and ventilator days to event. Patients with ventilator-associated condition had longer ICU stay versus controls; 24 days median (12–43 interquartile range) versus 7 days (4–14); (p
Source: Pediatric Critical Care Medicine - Category: Pediatrics Tags: Online Clinical Investigations Source Type: research

Related Links:

Platelet-dense ( δ) granules are important for platelet function. Platelets contribute to host defense and vascular integrity during pneumonia and sepsis, and δ granule products, including adenosine diphosphate (ADP), can influence inflammatory responses. We therefore aimed to study the role of platelet δ granule s in the host response during sepsis. Hermansky-Pudlak syndrome(Hps)3coa mice (with reduced δ granule content), mice treated with the platelet ADP receptor inhibitor clopidogrel, and appropriate control mice were infected with the human sepsis pathogenKlebsiella pneumoniae via the airways t...
Source: Journal of Innate Immunity - Category: Allergy & Immunology Source Type: research
Laura Fernandez-Garcia, Ant ón Ambroa, Lucia Blasco, Ines Bleriot, Maria López, Rocio Alvarez-Marin, Felipe Fernández-Cuenca, Luis Martinez-Martinez, Jordi Vila, Jesús Rodríguez-Baño, Jose Garnacho-Montero, Jose Miguel Cisneros, Alvaro Pascual, Jeronimo Pachón, German Bou, Younes Smani, Maria Tomás
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Publication date: Available online 15 December 2018Source: The Lancet NeurologyAuthor(s): Ralf Reilmann, Andrew McGarry, Igor D Grachev, Juha-Matti Savola, Beth Borowsky, Eli Eyal, Nicholas Gross, Douglas Langbehn, Robin Schubert, Anna Teige Wickenberg, Spyros Papapetropoulos, Michael Hayden, Ferdinando Squitieri, Karl Kieburtz, G Bernhard Landwehrmeyer, European Huntington's Disease Network, Pinky Agarwal, Karen E Anderson, Nasir A Aziz, Jean-Phillippe Azulay, Anne C Bachoud-LeviSummaryBackgroundPrevious trials have shown that pridopidine might reduce motor impairment in patients with Huntington's disease. The aim of this...
Source: The Lancet Neurology - Category: Neurology Source Type: research
Publication date: Available online 16 December 2018Source: Respiratory Medicine Case ReportsAuthor(s): Ryota Otoshi, Hideaki Yamakawa, Tamiko Takemura, Takuma Katano, Naoto Aiko, Goushi Matama, Kohsuke Isomoto, Tomohisa Baba, Eri Hagiwara, Takashi OguraAbstractA 66-year-old man, an ex-smoker, was referred to our hospital for slightly progressive respiratory symptoms of cough and dyspnea on exertion and chest abnormal shadow. Chest high-resolution computed tomography showed wide-ranging ground-glass attenuation and reticulation with lower lobe predominance. Bronchoalveolar lavage (BAL) fluid revealed a marked increase in ly...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
Publication date: Available online 15 December 2018Source: Respiratory Medicine Case ReportsAuthor(s): Yang Zhao, Wei GuoAbstractPrimary pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma is extremely rare. MALT lymphoma patients usually show no clinical symptoms or physical signs. Chest radiograph or computed tomography (CT) may confuse MALT lymphoma with other pulmonary diseases, which would lead to misdiagnosis or a delayed diagnosis. In the present study, a 33-year-old male patient had cough and fever. Chest CT showed consolidation on both sides. Those clinical symptoms disappeared after he had been misdiagnos...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
Publication date: Available online 15 December 2018Source: Respiratory Medicine Case ReportsAuthor(s): Keigo Okamoto, Jun HanaokaAbstractCombined subsegmentectomy (CSS) is procedure as diagnostic purpose adding sufficient surgical margin. Compared to other procedure, CSS is not common, with the surgical results also being controversial. We analyzed the patients who had undergoing CSS in the right upper lobe for ground glass opacity (GGO) -dominant nodules. Between April 2011 and March 2017, we experienced 7 cases underwent CSS. In all cases, three subsegments resection and lymph node dissection using Video-Assisted Thoraci...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
Authors: Duek OS, Ben Naftali Y, Bar-Lavie Y, Bahouth H, Ullmann Y Abstract BACKGROUND: Pneumonia is a major cause of morbidity and mortality in burn patients with inhalation injuries. An increased risk of pneumonia has been demonstrated in trauma and burn patients urgently intubated in the field vs. emergency departments (EDs). OBJECTIVES: To compare intubation setting (field vs. ED) and subsequent development of pneumonia in burn patients and to evaluate the indication for urgent intubation outside the hospital setting. METHODS: A retrospective medical records review was conducted on all intubated patient...
Source: The Israel Medical Association Journal - Category: General Medicine Tags: Isr Med Assoc J Source Type: research
In conclusion, we show that molecular technology could be applicable in the field of point-of-care testing in infectious disease, and its implementation will ensure the correct antimicrobial prescription for pediatric pneumonia patients. PMID: 30541996 [PubMed - in process]
Source: The Tohoku Journal of Experimental Medicine - Category: Research Authors: Tags: Tohoku J Exp Med Source Type: research
This study and extension phase are registered with ClinicalTrials.gov, number NCT01205152, and EudraCT, number 2009-009369-32.Findings11 participants were recruited between Oct 6, 2008, and Dec 4, 2009. Ten patients completed a 6 month treatment period and entered the extension phase; nine received asfotase alfa for at least 6 years and completed the study, with four being treated for more than 7 years. Skeletal healing was sustained over 7 years of treatment; all evaluable patients had RGI-C scores of at least +2 at year 6 (n=9; median score +2·0 [range 2·0–3·0]) and year 7 (n=7; median score +2...
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
This report presents a case of pneumonia-associated sepsis in a patient with a tracheostomy accompanied by third-stage larval Sarcophagidae. A 51-year-old male patient developed hypoxic brain injury after myocardial infarction 10 months ago before his admission to the hospital. Tracheostomy and percutaneous endoscopic gastrostomy were performed. Shortness of breath and fever were present for five days. The patient has been admitted to the emergency service with the reason for the deterioration of the general situation. The patient was unconscious. Purulent secretion in the tracheostomy area and bilateral crepitation rales ...
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
More News: Academia | Children | Databases & Libraries | Hospitals | Pediatrics | Pneumonia | Study