Researchers Discover Link between Gut Bacteria and the Effectiveness of Certain Cancer Drugs; Knowledge May Lead to New Types of Clinical Laboratory Tests

Microbiome is once again leading scientists toward a new understanding of how human gut bacteria can impact the efficacy and side-effects of certain cancer therapies Anatomic pathology researchers already know that a person’s genetics can affect the results of cancer treatments. Now it is becoming clear that a patient’s microbiome—which includes gut bacteria—may also impact […]
Source: Dark Daily - Category: Laboratory Medicine Authors: Tags: Instruments & Equipment Laboratory Instruments & Laboratory Equipment Laboratory Management and Operations Laboratory News Laboratory Pathology Laboratory Testing Albert Einstein College of Medicine anatomic pathology beta-glucuronidase Source Type: news

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Silvia Schenone Protein kinases have emerged as crucial targets for cancer therapy over the last decades. Since 2001, 40 and 39 kinase inhibitors have been approved by FDA and EMA, respectively, and the majority are antineoplastic drugs. Morevoer, many candidates are currently in clinical trials. We previously reported a small library of 4-aminoimidazole and 2-aminothiazole derivatives active as Src family kinase (SFK) inhibitors. Starting from these results, we decided to perform an optimization study applying a mix and match strategy to identify a more potent generation of 4-aminoimidazoles. Firstly, a computationa...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Ectopic expression of E3 ubiquitin-protein ligase 2 in glioma and enhances resistance to apoptosis through activating nuclear factor κ-light-chain-enhancer of B cells. Oncol Lett. 2018 Oct;16(4):4391-4399 Authors: Bai J, Xiao L, Tao Z, Cao B, Han Y, Fan W, Kong X, Ma X, Gao Y, Bi L, Chen W, Shi B, Liu X Abstract Nuclear factor κ-light-chain-enhancer of B cells (NF-κB) is one of the most important tumorigenic factors. Although it has been established that NF-κB is overly activated in human glioma cells, the molecular mechanisms that lead to the signal transduction to NF-κB ...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Authors: Yu Y, Cui J Abstract Modulation of the tumor microenvironment is becoming an increasingly popular research topic in the field of immunotherapy, and studies regarding immune checkpoint blockades and cancer immunotherapy have pushed cancer immunotherapy to a climax. Simultaneously, the manipulation of the immune regulatory pathway can create an effective immunotherapy strategy; however, the tumor microenvironment serves an important role in suppressing the antitumor immunity by its significant heterogeneity. A number of patients with cancer do not have a good response to monotherapy approaches; therefore, co...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
In conclusion, SP is a novel oral iron chelator with anti-cancer effects and few adverse side effects. This is the first report of SP in the literature. PMID: 30214682 [PubMed]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
This study manipulated a chrysin loaded bovine serum albumin nanoparticles (BSA NPs), which could solubilize the poorly water-soluble drug and increase the therapeutic efficacy of the drug. Chrysin (5, 7-dihydroxyflavone) is a natural flavonoid which have some significant biological effects on the processes of chemical defense. Chrysin loaded bovine serum albumin nanoparticles (Chrysin-BSA NPs) were synthesized by a simple desolvation procedure. The resultant Chrysin-BSA NPs showed a spherical shape, with a diameter of 97.5 ± 5.75 nm (mean ± SD) nm and a ζ-potential of - 11 mV. The in vitro d...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
Publication date: Available online 14 September 2018Source: Journal of Thermal BiologyAuthor(s): Hamid Fakhimikabir, Mohamad Bagher Tavakoli, Ali Zarrabi, Alireza Amouheidari, Soheila RahgozarAbstractThe therapeutic effect of polyglycerol coated iron oxide nanoparticles (PG-SPIONs, non-targeted nanoparticles) and folic acid-conjugated polyglycerol coated iron oxide nanoparticles (FA-PG-SPIONs, targeted nanoparticles) in combination with hyperthermia on viability of HeLa cells was investigated. It was observed that coated and uncoated SPIONs have spherical shapes with an average diameter of 17.9±2.85 nm and 5.4&...
Source: Journal of Thermal Biology - Category: Biology Source Type: research
Publication date: 15 January 2019Source: Chemical Engineering Journal, Volume 356Author(s): Huiting Bi, Yunlu Dai, Piaoping Yang, Jiating Xu, Dan Yang, Shili Gai, Fei He, Guanghui An, Chongna Zhong, Jun LinAbstractPhotodynamic therapy (PDT) has become a significant anticancer method by making full use of reactive oxygen species (ROS) to kill cancer cells. However, high concentration of reductive glutathione (GSH) in tumor site is an enemy, which can decrease the PDT efficacy due to ROS consumption property of reductive GSH. To overcome the problem, here we design an innovative nanoplatform, which could integrate PDT, chemo...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
We report the case of an acute coronary syndrome presumably induced by 5-FU in a patient with previously unknown and asymptomatic corotabelnary artery disease and with an estimated intermediate risk for cardiovascular events. Pre-chemotherapy risk assessment and optimal patient care are still not standardized in this clinical scenario.ResumoO 5-flurouracilo é um agente de primeira linha no tratamento de várias neoplasias. Associa-se frequentemente a toxicidade cardíaca, particularmente em doentes com doença coronária. O caso apresentado ilustra uma síndrome coronária aguda p...
Source: Revista Portuguesa de Cardiologia - Category: Cardiology Source Type: research
Publication date: Available online 31 August 2018Source: Acta Pharmaceutica Sinica BAuthor(s): Meng Li, Liwen Zhao, Tao Zhang, Yue Shu, Zhonggui He, Yan Ma, Dan Liu, Yongjun WangAbstractProdrug nanoassemblies, which can refrain from large excipients, achieve higher drug loading and control drug release, have been placed as the priority in drug delivery system. Reasoning that glutathione (GSH) and reactive oxygen species (ROS) are highly upgraded in tumor tissues which makes them attractive targets for drug delivery system, we designed and synthetized a novel prodrug which utilized mono thioether bond as a linker to bridge ...
Source: Acta Pharmaceutica Sinica B - Category: Cancer & Oncology Source Type: research
Publication date: 1 January 2019Source: Materials Science and Engineering: C, Volume 94Author(s): Jun Wang, Yu Lu, Shuting Li, Xin Wang, Yan Huang, Rupei TangAbstractTriblock copolymer PEG-block-poly(ortho ester urethane)-block-PEG (PEG-POEU-PEG) was conveniently prepared via polycondensation reaction between the ortho ester-containing diol and hexamethylene diisocyanate (HDI) at varying reaction time followed by termination with polyethylene glycol monomethyl ether (mPEG). PEG-POEU-PEG could further self-assemble into nano-scaled micelles. Ortho ester degradation in these micelles was significantly accelerated at pH 5.0...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
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