Changes in 10-year cardiovascular risk and behavioral risk factors in men in Crete, Greece, since the Seven Countries ’ Study (1960–1997)

This study aimed to assess changes in CVD-risk occurring since the Seven Countries’ Study.Subject and methodsSecondary analysis was performed in two cohorts of men (aged 40 –60 years) in Crete-Greece, in 1960 (Seven Countries’ Study’s participants) and 1997 (random sample of men of the same age and residence areas). The HeartScore was used to estimate the (1) 10-year CVD-risk and (2) 10-year CVD-risk based on body mass index (BMI), of 627 (1960 cohort) and 93 (1 997 cohort) Cretan men.ResultsBetween 1960 and 1997, 10-year CVD-risk (3.4 vs. 4.7%,P 
Source: Journal of Public Health - Category: Health Management Source Type: research

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Source: OnMedica Latest News - Category: UK Health Source Type: news
In this study, fluorescence emission spectroscopy and mass spectrometry (MALDI-TOF) were employed to define the putative interaction sites and their accessibility for the biologically important metals of Irving William Series.Key findingsSeveral hotspot residues in the ZAG scaffold involved in these interactions were mapped and their binding affinity score for each metal has been determined. Their binding abilities of these sites and aggregation propensities of ZAG were monitored by fluorescence emission spectroscopy.SignificanceThe prediction of such binding affinity with metals on the active sites and its impact on the c...
Source: Life Sciences - Category: Biology Source Type: research
Authors: Gluszewska A, Gryglewska B, Rewiuk K, Zarzycki B, Dzieza-Grudnik A, Kwater A, Major P, Budzynski A, Gasowski J, Grodzicki T Abstract Subclinical arterial damage connected with endothelial dysfunction is a common denominator of cardiovascular complications in a variety of metabolic diseases, including obesity. The aims of the study was to assess functional vascular changes measured by flow-mediated dilatation (FMD) and nitroglycerin-mediated dilation (NMD) of brachial artery, and to measure vascular structural alterations estimated by carotid intima-media complex thickness (IMT) in short- (10 days) and medi...
Source: Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research
ABSTRACT: Introduction: In high-income countries, persons of high socioeconomic status (SES) have a lower cardiovascular risk. However, in middle and low-income countries, the results are controversial. Objective: To evaluate the association between family income and cardiovascular risk factors in young adults. Methods: A total of 2,063 individuals of a birth cohort initiated in 1978/79 in the city of Ribeir ão Preto, Brazil, were evaluated at age of 23/25 years. Cardiovascular risk factors (hypertension, sedentary lifestyle, smoking, low high-density lipoprotein (HDL)-cholesterol, high low-density lipoprotein (LDL)...
Source: Revista Brasileira de Epidemiologia - Category: Epidemiology Source Type: research
Conclusions: In the search for more effective and less invasive therapies to help reverse the global acceleration of obesity and obesity-related disease OEA is a promising candidate; however, our data indicate that it is not an underlying mechanism of the effectiveness of VSG.
Source: Annals of Surgery - Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research
ConclusionOur findings suggest that consumption of a cafeteria diet increases sympathetic drive to the heart but not to the blood vessels, independent of impairment in baroreflex and chemoreflex functions. Other mechanisms may be involved in the increased cardiac sympathetic drive, and compensatory vascular mechanisms may prevent the development of hypertension in this model of obesity.
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
In conclusion, these results demonstrate that supplementation with N2-NBW potentially alleviates the development of obesity in HFD fed mice.Graphical abstractSupplementation with N2-NBW effectively alleviated the obesity-associated markers in the high-fat diet fed mice.
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Conditions:   Cholesterol, Elevated;   Overweight or Obesity Interventions:   Dietary Supplement: RS4 bar;   Dietary Supplement: Control bar Sponsors:   Kansas State University;   MGP Ingredients, Inc. Recruiting
Source: - Category: Research Source Type: clinical trials
AbstractMany obese patients are exposed to hypolipidemic and serotonin ‐norepinephrine reuptake inhibitor (SNRI) drugs. Statins are one of the most marketed drugs in the world to treat dyslipidemia, while sibutramine, a SNRI drug, is prescribed in some countries to treat obesity and is detected as an additive in many adulterated weight loss supplements marketed world wide. Previous studies reported adverse effects of isolated exposure to these drugs on male rat reproductive parameters. In the present work, we further investigated male reproductive toxicity of these drugs, administered in isolation or combination in adult...
Source: Journal of Applied Toxicology - Category: Toxicology Authors: Tags: RESEARCH ARTICLE Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
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