What Are Cutaneous Lesions Associated with Occult Spinal Dysraphism?

Discussion Neural tube defects are a group of disorders that arise during embryogenesis. They include anenephaly, exencephaly, meningmyelocoeles and encephalocoeles and other malformations including occult spinal dysraphism. Occult spinal dysraphism (OSD) has incomplete fusion of the midline elements of the spine including the bony, neural, and mesenchymal tissues but the abnormalities are covered by skin (ectodermal tissues) and therefore are not obvious. OSD has a higher risk of tethered spinal cord syndrome or other neurological/neurosurgical problems. Normally the caudal end of the spinal cord, the conus medullaris, hangs freely within the spinal column but is stabilized by the filum terminale. As the spinal column grows faster than the spinal cord, there is relative ascension of the conus medullaris during embryogenesis, reaching the adult level from birth to 2 months of age. The adult level is L2 to L3 for 98% of the population. Tethering occurs when a thickened filum terminale or mass does not allow normal ascension and damage to the spinal cord can occur because of ischemia or the mechanical traction. Tethered cord can produce a number of symptoms including bowel or bladder problems, back or leg pain, numbness or tingling, changes in leg strength or gait, muscle spasms, leg deformities, scoliosis, etc. Developmental regression of milestones previously obtained also can occur in children as a sign of tethered cord syndrome. Treatment is by freeing the conus medullaris....
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news

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In the clinic, I'm wearing respirator and face shield, but out in public, I'm un-masked. he/his/him
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Authors: Loh HH, Yee A, Loh HS, Kanagasundram S, Francis B, Lim LL Abstract PURPOSE: Polycystic ovarian syndrome (PCOS) is a common disorder characterized by clinical or biochemical hyperandrogenism and ovulary dysfunction. Female sexual dysfunction (FSD) adversely affects quality of life and interpersonal relationships. We aimed to compare the prevalence of FSD in women with and without PCOS. METHODS: We pooled data from 28 observational studies involving 6256 women. Apart from the total prevalence of FSD, subgroup analyses based on different PCOS diagnostic criteria and obesity status (body mass index [BMI]&t...
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. PMID: 32469304 [PubMed - as supplied by publisher]
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