Editorial Comment: Two-Year-Old Boy With Recurrent Seizures, Abnormal Movements, and Central Hypoventilation

In this issue, Drs Cohen and Wong-Kisiel describe an illustrative case of severe N-methyl-D-aspartate receptor (NMDAR) encephalitis with a protracted clinical course. They describe a positive response to aggressive treatment following suboptimal response to first-line immunosuppressive therapies. The case illustrates some important aspects of the early diagnosis and treatment of NMDAR antibody–mediated encephalitis that can be challenging in young children. In these cases, important clues to the diagnosis could be missed or attributed to other possible etiologies. The discussion thoroughly summarizes the current knowledge and limitations regarding the lack of standardized treatment protocols and the protracted course of some of these patients.
Source: Seminars in Pediatric Neurology - Category: Neurology Authors: Source Type: research