Selective regulation of osteoclast adhesion and spreading by PLC γ/PKCα-PKCδ/RhoA-Rac1 signaling.

In this study, we investigated the link between signal modulators known to M-CSF- and OPN-induced osteoclast adhesion and spreading. M-CSF- and OPN-induced osteoclast adhesion was achieved via activation of stepwise signals, including integrin αvβ3, PLCγ, PKCδ, and Rac1. Osteoclast spreading induced by M-CSF and OPN was shown to be controlled via sequential activation, consistent with the osteoclast adhesion processes. In contrast to osteoclast adhesion, osteoclast spreading induced by M-CSF and OPN was blocked via activation of PLCγ/PKCα/RhoA signaling. The combined results indicate that osteoclast adhesion and spreading are selectively regulated via PLCγ/PKCα-PKCδ/RhoA-Rac1 signaling.
PMID: 29301608 [PubMed - as supplied by publisher]

Source: BMB Reports - January 5, 2018 Category: Biochemistry Authors: Kim JM, Lee K, Jeong D Tags: BMB Rep Source Type: research