Polio: Mutated virus breaches vaccine protection

(University of Bonn) Thanks to effective vaccination, polio is considered nearly eradicated. Each year only a few hundred people are stricken worldwide. However, scientists of the University of Bonn, together with colleagues from Gabon, are reporting alarming findings: a mutated virus that was able to resist the vaccine protection to a considerable extent was found in victims of an outbreak in the Congo in 2010. The pathogen could also potentially have infected many people in Germany. The results appear now in the magazine PNAS.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

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This study was carried to i) investigate the circulation and genetic diversity of NPEV and polio vaccine isolates recovered from healthy children and Acute Flaccid Paralysis ( AFP) patients, ii) evaluate the occurrence of genetic recombination among EVs belonging to theEnterovirus C species (including PVs) and iii) identify the virological factors favoring multiple emergences of cVDPVs in DR Congo. The biological material considered in this study included i) a collection of 91 Sabin-like PVs, 54 cVDPVs and 150 NPEVs isolated from AFP patients between 2008 and 2012 in DR Congo and iii) a collection of 330 stool specimens co...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
(NEW YORK) — One morning last fall, 4-year-old Joey Wilcox woke up with the left side of his face drooping. It was the first sign of an unfolding nightmare. Three days later, Joey was in a hospital intensive care unit, unable to move his arms or legs or sit up. Spinal taps and other tests failed to find a cause. Doctors worried he was about to lose the ability to breathe. “It’s devastating,” said his father, Jeremy Wilcox, of Herndon, Virginia. “Your healthy child can catch a cold — and then become paralyzed.” Joey, who survived but still suffers some of the effects, was one of 228...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized illness medical onetime Source Type: news
[Dalsan Radio] Somalia kicked off a countrywide polio campaign, as part of ongoing efforts to sustain polio immunity and protection in response to the outbreaks of two strains of poliovirus currently circulating.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
This report updates (as of February 26, 2019) previous reports on circulating VDPV type 2 (cVDPV2) outbreaks during 2017-2018 in the Democratic Republic of the Congo (DRC) and in Somalia, which experienced a concurrent cVDPV type 3 (cVDPV3) outbreak* (2,3). In DRC, 42 cases have been reported in four cVDPV2 outbreaks; paralysis onset in the most recent case was October 7, 2018 (2). Challenges to interrupting transmission have included delays in outbreak-response supplementary immunization activities (SIAs) and difficulty reaching children in all areas. In Somalia, cVDPV2 and cVDPV3 were detected in sewage before the detect...
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
The Ohio teenager who made headlines for getting vaccinated against his mother’s wishes told the Senate on Tuesday that spreading vaccine misinformation is dangerous — but urged the public not to vilify those who do so. “Approaching this issue with the concern of education and addressing misinformation properly can cause change, as it did for me,” 18-year-old Ethan Lindenberger said while testifying before the Senate Health, Education, Labor and Pensions Committee on Tuesday. “Although the debate around vaccines is not necessarily centered around information, and concerns for health and sa...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime onetime vaccines Source Type: news
On 12 February, a circulating vaccine-derived poliovirus type 1 (cVDPV1) has been confirmed in Papua province, Indonesia. Two genetically-linked VDPV1 viruses were isolated from a child with acute flaccid paralysis (AFP) with onset of paralysis on 27 November 2018 and in a healthy community contact, a child whose stool sample was collected on 24 January 2019. The location of this healthy child, with the VDPV isolation, is in a remote village, approximately 3 –4 km away from the AFP case with onset of paralysis on 27 November 2018. Even though this province shares a border with Papua New Guinea, this outbreak is not l...
Source: WHO Disease Outbreaks - Category: Infectious Diseases Tags: news Source Type: news
Abstract BACKGROUND: Afghanistan remains among the three countries with endemic wild poliovirus transmission, and high population immunity levels are required to interrupt transmission and prevent outbreaks. Surveillance and vaccination of children in Afghanistan have been challenging due to security issues limiting accessibility in certain areas. METHODS: A serosurvey was conducted in 2013 within accessible enumeration areas (EAs) among children aged
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
ConclusionsConsiderable vaccination delay should be addressed within the vaccine hesitancy spectrum. Delays may induce susceptibility to vaccine-preventable disease outbreaks; tailored programmes to improve timeliness are required. PMID: 30755293 [PubMed - in process]
Source: Euro Surveill - Category: Infectious Diseases Authors: Tags: Euro Surveill Source Type: research
(The Translational Genomics Research Institute) Using multiple genomic sequencing tests, TGen identified a specific non-polio enterovirus -- EV-D68 -- among at least four children, according to a study published today in the scientific journal mBio. The finding is significant because AFM cases are continuing to increase and there has been no official recognition that this disease is being caused by EV-D68, which limits the research community's ability to develop preventative measures, such as new vaccines.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
As of October 2018, genetically-linked circulating vaccine-derived poliovirus type 2 (cVDPV2) isolates were detected in two cases from Haut-Katanga province (Mufunga-Sampwe district) in the Democratic Republic of the Congo. The first case was a 11-year old child who experienced onset of acute flaccid paralysis (AFP) on 6 October. The second case was a 29-month old child who experienced onset of symptoms on 7 October, and is a known contact of the first case. The isolated viruses are a new emergence and unrelated to previously-detected cVDPV2s affecting the country. This is the fourth distinct outbreak of cVDPV2 detected in...
Source: WHO Disease Outbreaks - Category: Infectious Diseases Tags: news Source Type: news
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