Akt2 Stabilizes ATP7A, a Copper Transporter for SOD3 (Extracellular Superoxide Dismutase), in Vascular Smooth Muscles: Novel Mechanism to Limit Endothelial Dysfunction in Type 2 Diabetes Mellitus.

CONCLUSION: Akt2 plays a critical role in ATP7A protein stabilization and translocation to plasma membrane in VSMCs, which contributes to full activation of vascular SOD3 that protects against endothelial dysfunction in T2DM. PMID: 29301787 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - Category: Cardiology Authors: Tags: Arterioscler Thromb Vasc Biol Source Type: research

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A highly selective and sensitive detection of insulin with chemiluminescence biosensor based on aptamer and oligonucleotide-AuNPs functionalized nanosilica @ graphene oxide aerogel. Anal Chim Acta. 2019 Dec 16;1089:152-164 Authors: Sun Y, Lin Y, Sun W, Han R, Luo C, Wang X, Wei Q Abstract A novel, highly selective and sensitive chemiluminescence (CL) biosensor for insulin (INS) detection was proposed based on aptamer and oligonucleotide-gold nanoparticles functionalized nanosilica @ graphene oxide aerogel. Initially, nanosilica functionalized graphene oxide aerogel (SiO2@GOAG) was successfully pr...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
New J. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9NJ04275J, PaperYingchun Gao, Yingguo Zhao, Xiao-Wei Song, Rong-Yi Huang, Yan Meng, Junwei Wang, Wenjing Wang, Chengneng Chen A copper complex based on the pentadentate aminopyridine ligand [(9-methyl-1,10-phenanthrolin-2-yl)methyl]bis-(pyridin-2-ylmethyl)amine (Dmphen-DPA), namely, [Cu(Dmphen-DPA)](ClO4)2 (1), was synthesized and characterized by elemental analysis, HR-MS spectra and X-ray single crystal diffraction. The complex... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Analyst, 2019, Accepted Manuscript DOI: 10.1039/C9AN01513B, PaperMayank ., Richa Rani, Ashutosh Singh, Neha Garg, Navneet Kaur, Narinder Singh Labelling and imaging of mitochondria and nucleolus have attracted very great attention because of the involvement of these cellular organelles in critical cellular activities. Therefore, a large number of mitochondria... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Analyst latest articles - Category: Chemistry Authors: Source Type: research
The common femoral vein (CFV) and iliac veins compose the common channel for venous drainage of the lower extremity. Occlusive venous thrombosis of the CFV and iliac veins is associated with severe post-thrombotic syndrome and in some cases with nonhealing vein ulcers. After percutaneous intervention, relative obstruction of the CFV can persist, leading to incomplete drainage of the femoral and profunda femoris venous systems, thereby mitigating the benefit of iliac vein recanalization and risking rethrombosis; associated restenosis intrastent could occur, resulting in a great challenge for endovascular management.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
In this study, we analyzed our experience with endovascular therapy in the treatment of symptomatic and asymptomatic femoropopliteal artery aneurysms.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
Synthetic marijuana use has been reported in the last years as a possible causative factor of different cardiovascular events, including myocardial infarction, ischemic stroke, intracranial bleeding, and cerebral vasospasm. One case of aortic thrombosis was also reported, but that was in a patient using cocaine and synthetic marijuana together. A case of lower limb thromboembolism and synthetic marijuana use has not been reported to date. Intoxication, material impurity, blood vessel reactivity, and chemical interaction with other drugs have been proposed as possible mechanisms of these events.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
This study aimed to review chara cteristics of multicultural Asian diabetic patients presenting to tertiary care with peripheral vascular complications and subsequent intervention rates and outcomes.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
The objective of this study was to review the outcomes after split-thickness skin grafting (SSG) of patients with peripheral artery disease and diabetic foot wounds in an Asian population.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
Diabetic foot ulcer (DFU) is a major health problem and remains a major cause of amputation across the world. Critical assessment of the relationship between peripheral artery disease, revascularization, and healing of DFU was performed. A new therapy has been claimed to prevent major amputations in advanced DFU. The intralesional injection of recombinant human epidermal growth factor (EGF) should often lead to satisfactory outcomes. The purpose of our study was to demonstrate the advantage of the combination of revascularization and EGF local infiltration in accelerating healing of DFU.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
The aim of this study was to assess the feasibility of aspiration mechanical thrombectomy of massive or submassive pulmonary embolism (PE) and deep venous thrombosis (DVT), in a single session, in patients with contraindications to thrombolysis.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
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