Depletion of S100A4+ stromal cells does not prevent HCC development but reduces the stem cell-like phenotype of the tumors.

In conclusion, this study demonstrated that S100A4+ cells do not contribute to HCC onset but maintain the stemness phenotype of the tumor. This study also suggests for the first time a crosstalk between inflammation and stemness.
PMID: 29303514 [PubMed - in process]

Source: Molecular Medicine - January 5, 2018 Category: Molecular Biology Authors: Jiao J, González Á, Stevenson HL, Gagea M, Sugimoto H, Kalluri R, Beretta L Tags: Exp Mol Med Source Type: research