Methoxetamine: a ketamine analog that is NOT bladder friendly

3.5 out of 5 stars Methoxetamine — a novel recreational drug with potent hallucinogenic properties. Zawilska JB. Toxicol Lett 2014 Aug 13. pii: S0378-4274(14)01298-3. doi: 10.1016/j.toxlet.2014.08.011. [Epub ahead of print] Abstract Methoxetamine (MXE) is a structural analog of ketamine, with effects that are similar but more intense and longer-lasting. Street names include: MXE Mexxy  M-ket MEX Kmax Special M MA “Legal ketamine” Minx Jipper Roflcoptr Since chronic exposure to ketamine is known to cause ulcerative cystitis, MXE is sometimes touted as “bladder friendly.” However, lack of clinical reports of GU tract injury associated with MXE most likely just reflects our limited experience with this drug. Recent animal studies have shown that mice exposed to MXE daily for 3 months develop bladder inflammation with fibrosis and renal damage. Clinical effects of MXE generally fall into one of two categories: Neurological: anxiety, agitation violent aggression, hallucinations, altered mental status, catatonia, cerebellar ataxia. Cardiovascular: tachycardia, hypertension, cardiac depression, respiratory depression. A hallmark of MXE overdose is cerebellar toxicity. Treatment is supportive, with fluids, benzodiazepines, and anti-emetics as needed. This is a well done, helpful review article, with an up-to-date set of references included articles published in 2014. Recommended. By the way, although as of this writing MXE is not a controlled substanc...
Source: The Poison Review - Category: Toxicology Authors: Tags: Medical bladder toxicity genitourinary toxicity ketamine methoxetamine MXE Source Type: news