Breast Implants Slightly Increase Risk of Breast ALCL

Implants tied to increased risk of anaplastic large - cell lymphoma; overall risk still very small
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Gynecology, Oncology, Pathology, Surgery, Journal, Source Type: news

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A study linking silicone gel-filled breast implants with several rare diseases should be viewed with caution, according to FDA. The authors of the study, published last week in the Annals of Surgery, say they looked at data from nearly 100,000 breast implant procedures gleaned from FDA-mandated postmarket studies for implants made by Johnson &Johnson's Mentor business, and by Allergan. The analysis showed that silicone implants are associated with higher rates of  Sjögren syndrome, scleroderma, rheumatoid arthritis, stillbirth, and melanoma. The researchers reported that 56% of the ...
Source: MDDI - Category: Medical Devices Authors: Tags: Implants Source Type: news
The FDA last week pushed back at a large study showing an association between silicone breast implants and some rare diseases, standing by its record of warning the public about their risks – despite granting approvals to a slew of the implants in recent years. The study, published Sept. 14 in the Annals of Surgery, looked at data from nearly 100,000 breast implant procedures the researchers gleaned from FDA-mandated post-approval studies for implants made by Johnson &Johnson (NYSE:JNJ) unit Mentor and by Allergan (NYSE: AGN). The analysis showed that silicone implants are associated with higher rates of Sj&...
Source: Mass Device - Category: Medical Devices Authors: Tags: Featured Food & Drug Administration (FDA) Women's Health Allergan johnsonandjohnson Source Type: news
ConclusionMost representatives agreed that further studies must be done. Concern is increasing, and the problem is known. Other factors involved may be considered, and the problem must not be ignored.No Level AssignedThis journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to
Source: Aesthetic Plastic Surgery - Category: Cosmetic Surgery Source Type: research
Breast implants are made of saline, silicone, or both. Some complications that may occur with implants include the implant bursting (rupture), unexplained swollen lymph nodes in the armpits, or a rare blood cancer called anaplastic large-cell lymphoma that may occur a year after surgery. Patients with implants and without symptoms should continue routine breast screening.
Source: Journal of the American College of Radiology : JACR - Category: Radiology Authors: Tags: Appropriate use criteria Source Type: research
ConclusionsBIA-ALCL is likely to be caused by a complex interplay of factors, allowing for the variation in clinical presentation and disease progression. Our survey has already shown a growing knowledge amongst breast surgeons in the UK and Ireland as well as a switch in practice in less than a third of consultants already.Level of Evidence: not ratable
Source: European Journal of Plastic Surgery - Category: Cosmetic Surgery Source Type: research
(Natural News) A 48-year-old British woman survived a rare blood cancer that was triggered by her breast implants. Known as anaplastic large cell lymphoma (ALCL), this type of cancer is said to be a result of a reaction between the white blood cells and the new generation of rough surfaced breast implants introduced a decade...
Source: - Category: Consumer Health News Source Type: news
Dave LevitanJun 6, 2018A case series of rare peripheral T-cell lymphoma that is associated with breast implants found that most cases have an indolent clinical course.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
CONCLUSION: In the literature, some articles describe correlation between connective tissue diseases and silicone breast implants, but the pathogenetic mechanisms are unknown. We report a rare case of breast morphea after positioning a silicone implant in a patient who had undergone mastectomy. This clinical report represents an interesting model of multidisciplinary management of a patient with breast cancer who developed an uncommon dermatologic disease. Further studies are needed to clarify the association between silicone implants and breast morphea. PMID: 29714655 [PubMed - as supplied by publisher]
Source: Tumori - Category: Cancer & Oncology Tags: Tumori Source Type: research
This article discusses different types of breast implants and some of the common adverse effects associated with them including contracture, rupture, leakage, and infection. The clinical and imaging appearances of these adverse effects are presented. In addition, the article describes findings and recommendations regarding rare breast implant-associated adverse effects such as anaplastic large cell lymphoma and breast fibromatosis. PMID: 29793920 [PubMed - in process]
Source: Radiologic Technology - Category: Radiology Authors: Tags: Radiol Technol Source Type: research
More than 500 women worldwide have developed a CD30+ T-cell lymphoma around breast implants, strongly suggesting a cause and effect relationship, and designated as breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). The mechanism of lymphomagenesis is unknown. Recently, a bacterial biofilm containing gram negative bacilli was discovered on the surface of breast implants associated with ALCL. We and others have described overexpression of the proto-oncogene JUNB and mutations of JAK1/2, TP53 and STAT3 in BIA-ALCL.
Source: Human Pathology - Category: Pathology Authors: Source Type: research
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