Breast Implants Slightly Increase Risk of Breast ALCL
Implants tied to increased risk of anaplastic large - cell lymphoma; overall risk still very small
More than 500 women worldwide have developed a CD30+ T-cell lymphoma around breast implants, strongly suggesting a cause and effect relationship, and designated as breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). The mechanism of lymphomagenesis is unknown. Recently, a bacterial biofilm containing gram negative bacilli was discovered on the surface of breast implants associated with ALCL. We and others have described overexpression of the proto-oncogene JUNB and mutations of JAK1/2, TP53 and STAT3 in BIA-ALCL.
The U.S. Food and Drug Administration (FDA) on March 21 released an update...Read more on AuntMinnie.comRelated Reading: FDA issues update on cancer linked to breast implants Use MRI to diagnose PIP breast implant ruptures, Dutch say MRI adds to cancer detection in women with breast implants Unusual breast implant sensations while flying: Mystery solved Radiotherapy complicates implant-based breast reconstruction
Women with breast implants have an increased risk of a type of lymphoma that can usually be cured by surgery alone — but not always.
As of September 30, 2017, the FDA has received a total of 414 medical device reports of anaplastic large cell lymphoma associated with breast implants, most involving implants with textured surfaces.News Alerts
Breast implant-associated anaplastic large cell lymphoma (BI-ALCL) is a rare T-cell lymphoma that arises around breast implants. Most patients manifest with periprosthetic effusion, whereas a subset of patients develops a tumor mass or lymph node involvement (LNI). The aim of this study is to describe the pathologic features of lymph nodes from patients with BI-ALCL and assess the prognostic impact of LNI. Clinical findings and histopathologic features of lymph nodes were assessed in 70 patients with BI-ALCL. LNI was defined by the histologic demonstration of ALCL in lymph nodes. Fourteen (20%) patients with BI-ALCL had LN...
ConclusionsThe epidemiology of the disease strongly suggests that the vast majority of cases are not a cancer that will inevitably progress without treatment. The findings presented in the manuscript provide supportive clinical evidence. Consequently, an alternative view of BIA-ALCL with implications for research, diagnosis and clinical management needs to be considered.Level of Evidence IVThis journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authorswww.springer.com/00266.
Women who get breast implants may be more likely to develop anaplastic large-cell lymphoma, a small Dutch study suggests.Reuters Health Information
(Reuters Health) - Women who get breast implants may be more likely to develop a rare type of cancer known as anaplastic large cell lymphoma, a small Dutch study suggests.
Women with breast implants face 400 times the risk for anaplastic large-cell lymphoma (ALCL) in the breast as women without implants, according to a...
Conclusions: The pathogenesis of BIA-ALCL remains unknown. The establishment of a national breast implant registry is needed to better understand some aspects of this disease. Future genetic studies on the population affected could clarify why only some patients with implants develop this disease.