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Preventing and treating acute chest syndrome in children with sickle cell disease

(Mary Ann Liebert, Inc./Genetic Engineering News) Acute chest syndrome (ACS), a potentially severe lung complication of sickle cell disease, increases a child's risk of respiratory failure, chronic lung disease, and prolonged hospitalization if not recognized early and treated effectively.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Sickle cell disease (SCD) is associated with episodic illnesses, multi-systemic affectations and end-organs damages. Otolaryngological related complications are not unexpected. Studies on the overall Otolaryngological pathologies in children with SCD relative to their non-SCD counterparts are scanty in Nigeria. We hypothesized that children with SCD are likely to have more otological burdens than their non-SCD counterparts. Thus, we embarked on this study to describe and compare the overall ear diseases burdens seen in children with sickle cell disease relative to their non-SCD counterparts.
Source: International Journal of Pediatric Otorhinolaryngology - Category: ENT & OMF Authors: Source Type: research
Chronic kidney disease (CKD) occurs in over one‐third of patients with sickle cell disease (SCD) and can progress to end‐stage renal disease. Unfortunately, current clinical assessments of kidney function are insensitive to early‐stage CKD. Previous studies have shown that diffusion magnetic resonance imaging (MRI) can sensitively detect regional renal microstructural changes associated with early‐stage CKD. However, previous MRI studies in patients with SCD have been largely limited to the detection of renal iron deposition assessed by T2* relaxometry. In this pilot imaging study, we compare MRI assessments of ren...
Source: NMR in Biomedicine - Category: Radiology Authors: Tags: RESEARCH ARTICLE Source Type: research
Authors: Nollan RH PMID: 29339944 [PubMed - in process]
Source: Journal of the Medical Library Association : JMLA - Category: Databases & Libraries Tags: J Med Libr Assoc Source Type: research
Conclusion In the largest study on SCD and pre-eclampsia in the world, we established SCD to be strongly associated with severe pre-eclampsia. Another unique finding is the synergistic effect of amplified risk for severe pre-eclampsia among mothers with the combined SCD-HIV status.
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
Condition:   Sickle Cell Disease Intervention:   Other: Medical file data collection Sponsor:   Hanane EL KENZ Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Sickle Cell Disease Intervention:   Drug: IMR-687 Sponsor:   Imara, Inc. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Sickle Cell Disease Intervention:   Other: Medical file data collection Sponsor:   Hanane EL KENZ Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Sickle Cell Disease Intervention:   Drug: IMR-687 Sponsor:   Imara, Inc. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Sickle Cell Disease Intervention:   Other: Medical file data collection Sponsor:   Hanane EL KENZ Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Sickle Cell Disease Intervention:   Drug: IMR-687 Sponsor:   Imara, Inc. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
More News: Children | Genetics | International Medicine & Public Health | Respiratory Medicine | Sickle Cell Anemia