A Simultaneous Mixed-Effects Pharmacokinetic Model for Nefopam, N -desmethylnefopam, and Nefopam N-Oxide in Human Plasma and Urine

ConclusionsA descriptive, robust and predictive parent –metabolite model has been developed using a population mixed-effects approach to characterize the pharmacokinetics of nefopam and its metabolites simultaneously in healthy subjects following oral administration of nefopam. The model may be used for dose selection, analysis of sparse data, identif ication of intrinsic and extrinsic factors, and to model the clinical effects of each analyte.
Source: European Journal of Drug Metabolism and Pharmacokinetics - Category: Drugs & Pharmacology Source Type: research