Transcriptional retargeting of herpes simplex virus for cell-specific replication to control cancer

ConclusionTranscriptional retargeting strategy holds great promise in retaining tumor specificity as well as full replication capacity of oncolytic virus in the target cell as urgently required by clinical trials. Future efforts should be aimed toward the development of multiple-component targeted oncolytic virus such as combing the transcriptional retargeting strategy and genetically attenuated modulation or post-transcriptional control that will be the most effective at generating truly tumor selective vectors.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research