Five- hit hypothesis in ATM gene: An individualized model in a breast cancer patient.
Five- hit hypothesis in ATM gene: An individualized model in a breast cancer patient. Front Biosci (Elite Ed). 2018 Mar 01;10:375-383 Authors: Mehdipour P, Azarnezhad A Abstract The aim of this study was to trace D1853N in a proband affected with primary BC to explore the molecular, cellular and structural aspects of ATM. Exon 37 and splicing regions were PCR-sequenced. Allelic location of the alterations was determined by molecular cloning. Possible impact of alterations was investigated through the bioinformatics and protein expression assays. Five genetic variants including IVS 36-91 AA>TT, IVS 36-8 T>C, D1853N, IVS 37+47 A>G, IVS 37+60 Del T were found in the target regions of ATM and all the alterations were occurred heterezygously. IVS 36-8 T>C and D1853N were observed in blood and tumor tissue, whilst splicing variants were only occurred in tumor tissue. Missense D1853N alteration seems to be effective on 2D and 3D structure of ATM protein and the probability of splicing found to be decreased by intronic variants. Protein expression of ATM also confirmed the occurrence and functional impact of alterations. Results reflect a five-hit hypothesis in a proband with BC that influence ATM, as a guard of genomic stability, at molecular, cellular, and structural levels. PMID: 29293464 [PubMed - in process]
Publication date: Available online 26 February 2020Source: Meta GeneAuthor(s): Salma Begum Bhyan, YongKiat Wee, Mingyu Luo, Yining Liu, Min Zhao
Conditions: Receptors, Estrogen; Genes, Erbb-2; Breast Neoplasms Interventions: Drug: Palbociclib (75, 100, 125 milligram [mg]); Drug: H3B-6545 (300, 450 mg) Sponsors: H3 Biomedicine Inc.; Eisai Inc. Not yet recruiting
Publication date: Available online 26 February 2020Source: Journal of the American College of RadiologyAuthor(s): Daniel B. Kopans, Kelly W. Biggs, Robert S. Pyatt, Dana Smetherman, Eric B. Friedberg
Publication date: Available online 26 February 2020Source: European Journal of RadiologyAuthor(s): Giovanna Mariscotti, Manuela Durando, Alberto Tagliafico, Pier Paolo Campanino, Davide Bosco, Cristina Casella, Riccardo Bussone, Ada Ala, Isabella Castellano, Anna Sapino, Laura Bergamasco, Paolo Fonio, Nehmat Houssami
Publication date: Available online 26 February 2020Source: Pathology - Research and PracticeAuthor(s): Fang Deng, Yaguang Weng, Xian Li, Teng Wang, Mengtian Fan, Qiong Shi
Conclusions Interventions that involve moderate to vigorous exercise 150 minutes for 3 times per week and in any modality may provide a better outcome for BC patients during adjuvant therapy. Implications for Practice Empowering BC patients to implement these exercise interventions could not only improve their health and QL, but also reduce fatigue, depression, and anxiety during adjuvant therapy.
Conclusions Breast cancer survivors did not routinely engage in healthy lifestyle behaviors. Significant temporal changes in healthy lifestyle behaviors and symptoms and significant associations among healthy lifestyle behaviors, symptoms, and demographic and clinical factors were noted in this study. Implications for Practice Knowing the temporal relationships among these variables provides insight that could be useful for nurses so they can encourage healthy lifestyle behaviors to mitigate symptoms throughout the cancer trajectory.
Conclusions When their mother was diagnosed with breast cancer, Chinese children experienced various negative feelings, although their daily life was not profoundly affected because of grandparents' help. However, children's concerns may be underestimated by their mothers. Fathers and grandparents also played an important role in the interactions with children. Implications for Practice Mothers in China need to understand their children's reactions in order to help them cope with the illness. Children's experiences should be further explored. The understanding of children from the perspectives of fathers and grandpare...
Conclusion Our study proved the heterogeneity of self-management behaviors and the influencing effect of treatment and psychosocial factors on the development of self-management behaviors in Chinese patients with breast cancer. Implications for Practice Health professionals should pay more attention to patients who are at higher risk of developing a poor self-management pattern. Targeted interventions should be developed across subpopulations and treatment periods accordingly.
To identify and analyze the stress factors and the level of stress. A year preceding the onset of breast cancer and depression in female patients. AbstractIntroductionThe aim of this study was to identify and analyze the stress factors and the level of stress a year preceding the onset of breast cancer and depression in the studied female patients.MethodsThe research in this work was mostly prospectively (clinical and analytical). During the research, Scale of Life Events ‐Paykel was applied. Stressful life events differed significantly between the groups. In the studied group, the following events were significantly mor...