Delayed ‐type hypersensitivity to vaccine aluminum adjuvant causing subcutaneous leg mass and urticaria in a child
Abstract
A 3‐year‐old girl presented with a 7‐month history of a waxing and waning left thigh mass associated with pruritus and erythema at the site of two previous DTaP‐HepB‐IPV vaccinations. Patch testing was positive to aluminum chloride, supporting a diagnosis of vaccine granuloma secondary to aluminum allergy; her symptoms had been well controlled with antihistamines and topical steroids. Injection site granulomas are a benign but potentially bothersome reaction to aluminum‐containing immunizations that can be supportively managed, and we encourage strict adherence to the recommended vaccine schedule in this setting. Patch testing is a sensitive, noninvasive diagnostic tool for patients presenting with this clinical finding, and dermatologist awareness can prevent unnecessary medical examination and provide reassurance.
Source: Pediatric Dermatology - Category: Dermatology Authors: Samantha C. Gordon, Diana W. Bartenstein, Shahein H. Tajmir, Johanna S. Song, Elena B. Hawryluk Tags: CASE REPORT Source Type: research
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