Prognostic Role of Tumoral PDL1 Expression and Peritumoral FoxP3+ Lymphocytes in Vulvar Melanomas

Prognostic role of PDL1 expression, CD8+ and FoxP3+ lymphocytes in vulvar melanomas has not been studied. We correlated PDL1 expression, and CD8+ and FoxP3+ immune infiltrates with clinicopathologic variables and patient outcomes in a series of 75 vulvar melanomas. Tumoral PDL1 expression (>5%) was seen in 23% of cases. By Fisher ’s Exact test, PDL1 expression and peritumoral FoxP3+ lymphocytes significantly correlated with less disease-specific death. By linear regression analysis, correlations between tumoral PDL1 expression with the density of tumoral CD8+ and peritumoral CD8+ lymphocytes; tumoral FoxP3+ with tumoral CD 8+ lymphocytes; and peritumoral FoxP3+ with peritumoral CD8+ lymphocytes were observed.

Source: Human Pathology - January 4, 2018 Category: Pathology Authors: Agata Ch łopik, M. Angelica Selim, Yan Peng, Cheng-Lin Wu, Gemma Tell-Marti, Kristen M. Paral, Sara C. Shalin, Stefan Kraft, Chao-Kai Hsu, Christopher R. Shea, Susana Puig, Maria-Teresa Fernandez-Figueras, Wojciech Biernat, Janusz Ryś, Andrzej Marszalek Tags: Original contribution Source Type: research