[Articles] Daytime variation of perioperative myocardial injury in cardiac surgery and its prevention by Rev-Erb α antagonism: a single-centre propensity-matched cohort study and a randomised study

Perioperative myocardial injury is transcriptionally orchestrated by the circadian clock in patients undergoing aortic valve replacement, and Rev-Erb α antagonism seems to be a pharmacological strategy for cardioprotection. Afternoon surgery might provide perioperative myocardial protection and lead to improved patient outcomes compared with morning surgery.

Source: LANCET - October 26, 2017 Category: General Medicine Authors: David Montaigne, Xavier Marechal, Thomas Modine, Augustin Coisne, St éphanie Mouton, Georges Fayad, Sandro Ninni, Cédric Klein, Staniel Ortmans, Claire Seunes, Charlotte Potelle, Alexandre Berthier, Celine Gheeraert, Catherine Piveteau, Rebecca Deprez, Tags: Articles Source Type: research