[Correspondence] How does azithromycin improve asthma exacerbations? – Author's reply

Two key findings of the AMAZES trial1 are relevant to asthma management. First, the addition of low-dose azithromycin to a combination of inhaled corticosteroids and long-acting bronchodilators led to a clinically significant reduction in asthma exacerbations in adults with poorly controlled asthma. This finding provides an additional therapeutic option for these patients. Second, the effect occurred equally in both eosinophilic and non-eosinophilic asthma, by an as yet unidentified mechanism, but acting on pathways other than type 2 inflammation.

Source: LANCET - January 5, 2018 Category: General Medicine Authors: Peter G Gibson Tags: Correspondence Source Type: research