Blood Levels of Caffeine May Help Diagnose Parkinson's (CME/CE)

(MedPage Today) -- Study finds decreased metabolites in early disease, regardless of caffeine consumption
Source: MedPage Today Primary Care - Category: Primary Care Source Type: news

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Researchers at the Sorbonne University in Paris studied 411 Parkinson's patients who had taken dopamine agonists over a period of three years to make the conclusion.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Authors: Abstract Parkinson\'s disease (PD) is often accompanied by significant changes in emotionality, such as apathy, anhedonia, anxiety and depression. The present review summarizes the empirical evidence, including amygdala changes and psychological changes in emotionality in people suffering with PD. Seventeen empirical full-text articles including research on both amygdala and emotionality in PD were reviewed.The changes in amygdala volumes as well as changes in binding potentials, functional connectivity, regional homogeneity and regional cerebral blood flow were found to have various impacts on emotionali...
Source: Neuroendocrinology Letters - Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research
Conclusions: This pilot study suggests that FPP AOT is a feasible intervention and the research protocol designed would be suitable, with minor modifications, for the conduction of a subsequent stage 2 trial designed to verify the hypothesis that the adjunct of FPP AOT might improve motor performance in individuals with IPD.
Source: Journal of Geriatric Physical Therapy - Category: Physiotherapy Tags: Research Reports Source Type: research
WEDNESDAY, June 20, 2018 -- Compulsive gambling. Shopping until your money has run out. Eating until you've grown obese. Relentless sexual risk-taking. Medications that restore normal movement in patients with Parkinson's disease can unlock their...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Conditions:   Parkinson Disease;   Movement Disorders;   Neuro-Degenerative Disease Interventions:   Other: Golf Instruction;   Other: Tai Chi Class Sponsor:   Massachusetts General Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Sue-Jin Lin, Tobias R. Baumeister, Saurabh Garg, Martin J. McKeown
Source: Frontiers in Neurology - Category: Neurology Source Type: research
The objective of this review is to provide a broad overview on current strategies for brain drug delivery and related subjects from the past five years. It is hoped that this review could inspire readers to discover possible approaches to deliver drugs into the brain. After an initial overview of the BBB structure and function in both healthy and pathological conditions, this review re-visits, according to recent publications, some questions that are controversial, such as whether nanoparticles by themselves could cross the BBB and whether drugs are specifically transferred to the brain by actively targeted nanoparticles. ...
Source: Theranostics - Category: Molecular Biology Authors: Tags: Review Source Type: research
Conclusion: This novel CPC-UTMD formulation approach could be an effective, safe and amenable choice with higher therapeutic relevance and fewer unwanted complications than conventional chemotherapeutics delivery systems for PD treatment in the near future.
Source: Theranostics - Category: Molecular Biology Authors: Tags: Research Paper Source Type: research
Anna-Maija Penttinen, Ilmari Parkkinen, Merja H. Voutilainen, Maryna Koskela, Susanne B äck, Anna Their, Christopher T. Richie, Andrii Domanskyi, Brandon K. Harvey, Raimo K. Tuominen, Liina Nevalaita, Mart Saarma, Mikko Airavaara
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Publication date: 14 September 2018 Source:Neuroscience Letters, Volume 683 Author(s): Gang Du, Ping Zhuang, Yuqing Zhang, Jianyu Li, Yongjie Li We compared the firing rates and proportion of patterns of oscillatory neurons in the subthalamic nucleus (STN), globus pallidus internus (GPi), and ventrolateral thalamus (VL) in Parkinson disease (PD). Twenty-nine patients with PD who underwent stereotactic neurosurgery were included in the study. Microelectrode recordings in the STN (n = 16), GPi (n = 9), and VL (n = 9) were performed. Power spectral analysis was used to explore neuronal oscillation. Of 76 STN neur...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
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