Blood Levels of Caffeine May Help Diagnose Parkinson's (CME/CE)
(MedPage Today) -- Study finds decreased metabolites in early disease, regardless of caffeine consumption
Michaela D. Gjerstad, Guido Alves, Jodi Maple-Gr ødem
Researchers from Georgetown University Medical Center in Washington DC have discovered blocking a certain protein in the brain can clear away nerve damaging build-ups.
(Georgetown University Medical Center) A team of neurologists at Georgetown University Medical Center has found that inhibiting the USP13 molecule may be a therapeutic target in Parkinson's disease and other similar forms of neurodegeneration.
Authors: Porta M, Pilloni G, Pili R, Casula C, Murgia M, Cossu G, Pau M Abstract Background: Although physical activity (PA) is known to be beneficial in improving motor symptoms of people with Parkinson's disease (pwPD), little is known about the relationship between gait patterns and features of PA performed during daily life. Objective: To verify the existence of possible relationships between spatiotemporal and kinematic parameters of gait and amount/intensity of PA, both instrumentally assessed. Methods: Eighteen individuals affected by PD (10F and 8M, age 68.0 ± 10.8 years, 1.5 ≤ Hoehn and Yahr (H&Y)
Scientists studying the tissue bequeathed to the Sydney Brain Bank hope it will lead them to an eventual cure for neurodegenerative diseasesIt ’s a rainy Wednesday morning and Dr Andrew Affleck is driving more carefully than usual on his way to the Neuroscience Research Australia building in Randwick.It ’s not just the slick, crowded roads putting the edge on his caution; in the boot of his car, cocooned in several layers of protective container and nestled in ice, is the brain of a human being who was alive only a few hours earlier.Continue reading...
In this study, BV2 microglial cells were stimulated with interferon-gamma and lipopolysaccharide and treated with GYY4137. The agent did not influence the viability of BV2 cells in concentrations up to 200 μM. It inhibited tumor necrosis factor but not interleukin-6 production. Expression of CD40 and CD86 were reduced under the influence of the donor. The phagocytic ability of BV2 cells and nitric oxide production were also affected by the agent. Surprisingly, GYY4137 upregulated generation of reactive oxygen species (ROS) by BV2 cells. The effect was mimicked by another H2S donor, Na2S, and it was not reproduced in...
Authors: Yang HJ PMID: 30416411 [PubMed - in process]
Conclusion: We found that CMBs are more frequent in PD patients than in controls, especially in those with the PIGD subtype and CMBs on the lobar area. Further study investigating the pathogenetic significance of CMBs is required. PMID: 30416409 [PubMed - in process]
PARKINSON ’S disease symptoms tend to develop slowly over a long period of time, but can include tremors and muscle stiffness. One of the more common signs of the neurodegenerative condition is a change to the way you walk - if you walk like this, you could be at risk.
The Journal of Physical Chemistry CDOI: 10.1021/acs.jpcc.8b06355