Long ‐term cardiovascular reprogramming by short‐term perinatal exposure to nicotine's main metabolite cotinine

ConclusionCotinine has subtle, enduring developmental consequences. Some cardiovascular effects of nicotine can plausibly arise via conversion into cotinine. Low‐level exposure to this metabolite may pose unrecognised perinatal risks. Adults must avoid inadvertently exposing a foetus or infant to cotinine as well as nicotine.

Source: Acta Paediatrica - January 4, 2018 Category: Pediatrics Authors: Stefano Bastianini, Viviana Lo Martire, Alessandro Silvani, Giovanna Zoccoli, Chiara Berteotti, Hugo Lagercrantz, Anders Arner, Gary Cohen Tags: Regular Article Source Type: research